{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:58:21Z","timestamp":1778990301455,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Background and Purpose<\/jats:title>Among the pathogenic mechanisms of asthma, a role for oxidative\/nitrosative stress has been well documented. Recent evidence suggests that histamine H4<\/jats:sub><\/jats:styled-content> receptors play a modulatory role in allergic inflammation. Here we report the effects of compound JNJ<\/jats:styled-content> 7777120 (JNJ<\/jats:styled-content>), a selective H4<\/jats:sub><\/jats:styled-content> receptor antagonist, on antigen\u2010induced airway inflammation, paying special attention to its effects on lipocortin\u20101 (LC<\/jats:styled-content>\u20101\/annexin\u2010A1<\/jats:styled-content>), a 37 kDA<\/jats:styled-content> anti\u2010inflammatory protein that plays a key role in the production of inflammatory mediators.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>Ovalbumin (OA<\/jats:styled-content>)\u2010sensitized guinea pigs placed in a respiratory chamber were challenged with antigen. JNJ<\/jats:styled-content> (5, 7.5 and 10\u2009mg\u00b7kg\u22121<\/jats:sup>) was given i.p. for 4 days before antigen challenge. Respiratory parameters were recorded. Bronchoalveolar lavage (BAL<\/jats:styled-content>) fluid was collected and lung specimens taken for further analyses 1\u2009h after antigen challenge. In BAL<\/jats:styled-content> fluid, levels of LC<\/jats:styled-content>\u20101, PGD2<\/jats:sub><\/jats:styled-content>, LTB4<\/jats:sub><\/jats:styled-content> and TNF\u2010\u03b1<\/jats:styled-content> were measured. In lung tissue samples, myeloperoxidase, caspase\u20103 and M<\/jats:styled-content>n\u2010superoxide dismutase activities and 8\u2010hydroxy\u20102\u2010deoxyguanosine levels were measured.<\/jats:p><\/jats:sec>Key Results<\/jats:title>OA<\/jats:styled-content> challenge decreased LC<\/jats:styled-content>\u20101 levels in BAL<\/jats:styled-content> fluid, induced cough, dyspnoea and bronchoconstriction and increased PGD2<\/jats:sub><\/jats:styled-content>, LTB4<\/jats:sub><\/jats:styled-content> and TNF<\/jats:styled-content>\u2010\u03b1 levels in lung tissue. Treatment with JNJ<\/jats:styled-content> dose\u2010dependently increased levels of LC<\/jats:styled-content>\u20101, reduced respiratory abnormalities and lowered levels of PGD2<\/jats:sub><\/jats:styled-content>, LTB4<\/jats:sub><\/jats:styled-content> and TNF<\/jats:styled-content>\u2010\u03b1 in BAL<\/jats:styled-content> fluid.<\/jats:p><\/jats:sec>Conclusions and Implications<\/jats:title>Antigen\u2010induced asthma\u2010like reactions in guinea pigs decreased levels of LC<\/jats:styled-content>\u20101 and increased TNF<\/jats:styled-content>\u2010\u03b1 and eicosanoid production. JNJ<\/jats:styled-content> pretreatment reduced allergic asthmatic responses and airway inflammation, an effect associated with LC<\/jats:styled-content>\u20101 up\u2010regulation.<\/jats:p><\/jats:sec>Linked Articles<\/jats:title>This article is part of a themed issue on Histamine Pharmacology Update. To view the other articles in this issue visit http:\/\/dx.doi.org\/\n10.1111\/bph.2013.170.issue\u20101<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12264","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T12:55:32Z","timestamp":1370350532000},"page":"200-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A selective antagonist of histamine H4<\/sub><\/scp> receptors prevents antigen\u2010induced airway inflammation and bronchoconstriction in guinea pigs: involvement of lipocortin\u20101"],"prefix":"10.1111","volume":"170","author":[{"given":"T","family":"Somma","sequence":"first","affiliation":[{"name":"Department of Preclinical and Clinical Pharmacology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Cinci","sequence":"additional","affiliation":[{"name":"Department of Preclinical and Clinical Pharmacology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Formicola","sequence":"additional","affiliation":[{"name":"Department of Preclinical and Clinical Pharmacology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Preclinical and Clinical Pharmacology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Thurmond","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development L.L.C. San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ennis","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Research Group The Queen's University of Belfast Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Forensic Medicine Section of Histology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of Preclinical and Clinical Pharmacology University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01649_1.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00278-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2580617"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.166"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403334101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.080473"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9903102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200400895"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0192"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0318"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.02.041"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/328270a0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3428"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62288-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.252"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.7062"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2012.08.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.5.1241"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00258.x"},{"key":"e_1_2_8_22_1","first-page":"253","article-title":"International Union of Pharmacology. 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