{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:28:16Z","timestamp":1785767296883,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Background and Purpose<\/jats:title>AVE<\/jats:styled-content> 0991 (AVE<\/jats:styled-content>) is a non\u2010peptide compound, mimic of the angiotensin (A<\/jats:styled-content>ng)\u2010(1\u20137) actions in many tissues and pathophysiological states. Here, we have investigated the effect of AVE<\/jats:styled-content> on pulmonary remodelling in a murine model of ovalbumin (OVA<\/jats:styled-content>)\u2010induced chronic allergic lung inflammation.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>We used BALB<\/jats:styled-content>\/c mice (6\u20138 weeks old) and induced chronic allergic lung inflammation by OVA<\/jats:styled-content> sensitization (20\u2009\u03bcg\u00b7mouse\u22121<\/jats:sup>, i.p., four times, 14 days apart) and OVA<\/jats:styled-content> challenge (1%, nebulised during 30\u2009min, three times per\u00b7week, for 4 weeks). Control and AVE<\/jats:styled-content> groups were given saline i.p and challenged with saline. AVE<\/jats:styled-content> treatment (1\u2009mg\u00b7kg\u22121<\/jats:sup>\u00b7per day, s.c.) or saline (100\u2009\u03bcL\u00b7kg\u22121<\/jats:sup>\u00b7per day, s.c.) was given during the challenge period. Mice were anaesthetized 72\u2009h after the last challenge and blood and lungs collected. In some animals, primary bronchi were isolated to test contractile responses. Cytokines were evaluated in bronchoalveolar lavage (BAL<\/jats:styled-content>) and lung homogenates.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Treatment with AVE<\/jats:styled-content> of OVA sensitised and challenged mice attenuated the altered contractile response to carbachol in bronchial rings and reversed the increased airway wall and pulmonary vasculature thickness and right ventricular hypertrophy. Furthermore, AVE<\/jats:styled-content> reduced IL<\/jats:styled-content>\u20105 and increased IL<\/jats:styled-content>\u201010 levels in the BAL<\/jats:styled-content>, accompanied by decreased A<\/jats:styled-content>ng II<\/jats:styled-content> levels in lungs.<\/jats:p><\/jats:sec>Conclusions and Implications<\/jats:title>AVE<\/jats:styled-content> treatment prevented pulmonary remodelling, inflammation and right ventricular hypertrophy in OVA<\/jats:styled-content> mice, suggesting that A<\/jats:styled-content>ng\u2010(1\u20137) receptor agonists are a new possibility for the treatment of pulmonary remodelling induced by chronic asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12318","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T14:25:32Z","timestamp":1376490332000},"page":"835-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["AVE<\/scp> 0991, a non\u2010peptide mimic of angiotensin\u2010(1\u20137) effects, attenuates pulmonary remodelling in a model of chronic asthma"],"prefix":"10.1111","volume":"170","author":[{"given":"M G","family":"Rodrigues\u2010Machado","sequence":"first","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Cardoso","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Kangussu","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Murari","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Caliari","sequence":"additional","affiliation":[{"name":"Department of Pathology Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Oliveira","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Cara","sequence":"additional","affiliation":[{"name":"Department of Morphology Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L M","family":"Noviello","sequence":"additional","affiliation":[{"name":"Department of Morphology Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F D","family":"Marques","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Pereira","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology and Biophysics Biological Sciences Institute Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Q","family":"Lautner","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics (INCT\u2010NANOBIOFAR) Department of Physiology 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