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Progress in the understanding of\n                    <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content>\n                    \u2010based mechanisms has opened up new perspectives in therapeutics for the treatment of several diseases including ocular disorders. The eye is currently considered a good target for\n                    <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content>\n                    therapy mainly because it is a confined compartment and, therefore, enables local delivery of small\u2010interfering RNAs (\n                    <jats:styled-content style=\"fixed-case\">siRNA<\/jats:styled-content>\n                    s) by topical instillation or direct injection. However, delivery strategies that protect the siRNAs from degradation and are suitable for long\u2010term treatment would be help to improve the efficacy of\n                    <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content>\n                    \u2010based therapies for ocular pathologies.\n                    <jats:styled-content style=\"fixed-case\">siRNA<\/jats:styled-content>\n                    s targeting critical molecules involved in the pathogenesis of glaucoma, retinitis pigmentosa and neovascular eye diseases (age\u2010related macular degeneration, diabetic retinopathy and corneal neovascularization) have been tested in experimental animal models, and clinical trials have been conducted with some of them. This review provides an update on the progress of\n                    <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content>\n                    in ocular therapeutics, discussing the advantages and drawbacks of\n                    <jats:styled-content style=\"fixed-case\">RNAi<\/jats:styled-content>\n                    \u2010based therapeutics compared to previous treatments.\n                  <\/jats:p>","DOI":"10.1111\/bph.12330","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T10:31:44Z","timestamp":1376476304000},"page":"730-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Small\u2010interfering\n                    <scp>RNA<\/scp>\n                    s (\n                    <scp>siRNA<\/scp>\n                    s) as a promising tool for ocular therapy"],"prefix":"10.1111","volume":"170","author":[{"given":"A","family":"Guzman\u2010Aranguez","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Loma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pintor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.54"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01649_1.x"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.12.012"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1635"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005073"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5121"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.039"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.32"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.2580"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.03.008"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411233200"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth854"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0052"},{"key":"e_1_2_18_16_1","first-page":"1848","article-title":"Bevacizumab neutralizes the protective effect of vascular endothelial growth factor on retinal ganglion cells","volume":"16","author":"Brar VS","year":"2010","journal-title":"Mol Vis"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1780169"},{"key":"e_1_2_18_18_1","unstructured":"BruckerA(2006).Small interfering RNA (CAND5) for the treatment of subfoveal choroidal neovascularization due to age\u2010related macular degeneration.Retina society. 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