{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:58:29Z","timestamp":1773961109817,"version":"3.50.1"},"reference-count":106,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["AM103\/10-1"],"award-info":[{"award-number":["AM103\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["IG18\/13-1"],"award-info":[{"award-number":["IG18\/13-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Bone tissue is subjected to continuous remodelling, replacing old or damaged bone throughout life. In bone remodelling, the coordinated activities of bone\u2010forming osteoblasts and bone\u2010resorbing osteoclasts ensure the maintenance of bone mass and strength. In early life, the balance of these cellular activities is tightly regulated by various factors, including systemic hormones, the mechanical environment and locally released growth factors. Age\u2010related changes in the activity of these factors in bone remodelling can result in diseases with low bone mass, such as osteoporosis. Osteoporosis is a systemic and age\u2010related skeletal disease characterized by low bone mass and structural degeneration of bone tissue, predisposing the patient to an increased fracture risk. The growth factor midkine (<jats:styled-content style=\"fixed-case\">Mdk<\/jats:styled-content>) plays a key role in bone remodelling and it is expressed during bone formation and fracture repair. Using a mouse deficient in Mdk, our group have identified this protein as a negative regulator of bone formation and mechanically induced bone remodelling. Thus, specific <jats:styled-content style=\"fixed-case\">Mdk<\/jats:styled-content> antagonists might represent a therapeutic option for diseases characterized by low bone mass, such as osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Midkine. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/bph.2014.171.issue-4\">http:\/\/dx.doi.org\/10.1111\/bph.2014.171.issue\u20104<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12412","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:38:34Z","timestamp":1381250314000},"page":"870-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of midkine in skeletal remodelling"],"prefix":"10.1111","volume":"171","author":[{"given":"A","family":"Liedert","sequence":"first","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics Center of Musculoskeletal Research University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Schinke","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010 Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ignatius","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics Center of Musculoskeletal Research University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010 Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.11.017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.0998"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200011)22:11<970::AID-BIES3>3.0.CO;2-L"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.04.593"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.6.960"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2332"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3074"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2012.02717.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10048.RA"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08827-X"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-1880-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81558-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.23"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9153-1"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130203"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0503"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.015"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00256-3"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.035"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01660"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63208-7"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014864131288"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5477.265"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220902841961"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.004"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.03.017"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm84"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.3.607"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01654"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1030"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153233"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201089"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1060"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12466608"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01428-09"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00842-6"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.08.017"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0773-z"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.214"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.12.019"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4234-5_19"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.08.002"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1528"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12474"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0132"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20175"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7188"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.020487997"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.129.1.267"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.10.044"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01423"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2006.01028.x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a003231"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.86.410"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795164167"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0479-3"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1998.00231.x"},{"key":"e_1_2_12_61_1","first-page":"197","article-title":"Expression of syndecan\u20101 and \u20103 during embryogenesis of the central nervous system in relation to binding with midkine","volume":"121","author":"Nakanishi T","year":"1997","journal-title":"J Biochem"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.75"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0501-37"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v024a27"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22327"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.7.1132"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/956"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00332-2"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.77.4"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.239"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166209"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1787-y"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026332"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060709"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-011-0050-7"},{"key":"e_1_2_12_77_1","first-page":"212","article-title":"Osteopenic mice: animal models of the aging skeleton","volume":"2","author":"Priemel M","year":"2002","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005911200"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.041087"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945008784911778"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007997"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-8-200910200-00006"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.446"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-012-0099-y"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.8.061505.095721"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.10.028"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1221"},{"key":"e_1_2_12_88_1","first-page":"275","article-title":"Transgenic and knock out mice in skeletal research. Towards a molecular understanding of the mammalian skeleton","volume":"1","author":"Schilling AF","year":"2001","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.11.009"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010309"},{"key":"e_1_2_12_91_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/oxfordjournals.jbchem.a124898","article-title":"Restricted expression of Xenopus midkine gene during early development","volume":"118","author":"Sekiguchi K","year":"1995","journal-title":"J Biochem"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021773"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02456-7"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.1.C1"},{"key":"e_1_2_12_95_1","first-page":"345","article-title":"Receptor activator of nuclear factor\u2010kappaB ligand and osteoprotegerin: maintaining the balance to prevent bone loss","volume":"5","author":"Trouvin AP","year":"2010","journal-title":"Clin Interv Aging"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2305"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211104010014"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709592105"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1100\/2011\/517152"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.06.044"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.123"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2012.04.003"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1593"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.11.4677-4684.2004"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwg001"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700428"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-1909-x"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.12412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.12412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.12412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.12412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:26:42Z","timestamp":1694633202000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.12412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,24]]},"references-count":106,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/bph.12412"],"URL":"https:\/\/doi.org\/10.1111\/bph.12412","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,24]]},"assertion":[{"value":"2013-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}