{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:05Z","timestamp":1791221645312,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Adamed Ltd."},{"name":"National Centre for Research and Development (NCBR)","award":["KB\/88\/12655\/IT1-C\/U\/08"],"award-info":[{"award-number":["KB\/88\/12655\/IT1-C\/U\/08"]}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Many dementia patients exhibit behavioural and psychological symptoms (<jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with motor and cardiac side effects, which are problematic in elderly patients. A need therefore exists for drugs that are better suited for the treatment of<jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>We used<jats:italic>in vitro<\/jats:italic>cellular and<jats:italic>in vivo<\/jats:italic>behavioural tests to characterize<jats:styled-content style=\"fixed-case\">ADN<\/jats:styled-content>\u20101184, a novel arylsulfonamide ligand with potential utility for treatment of<jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ADN<\/jats:styled-content>\u20101184 exhibits substantial 5\u2010<jats:styled-content style=\"fixed-case\">HT<jats:sub>6<\/jats:sub><\/jats:styled-content>\/5\u2010<jats:styled-content style=\"fixed-case\">HT<jats:sub>7<\/jats:sub><\/jats:styled-content>\/5\u2010<jats:styled-content style=\"fixed-case\">HT<jats:sub>2A<\/jats:sub><\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<jats:sub>2<\/jats:sub><\/jats:styled-content>receptor affinity and antagonist properties<jats:italic>in vitro<\/jats:italic>. In tests of antipsychotic\u2010like activity, it reversed<jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u2010801\u2010induced hyperactivity and stereotypies and inhibited conditioned avoidance response (<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>= 3\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>i.p.). Remarkably,<jats:styled-content style=\"fixed-case\">ADN<\/jats:styled-content>\u20101184 also reduced immobility time in the forced swim test at low doses (0.3 and 1\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>i.p.; higher doses were not significantly active). Notably, up to 30\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup><jats:styled-content style=\"fixed-case\">ADN<\/jats:styled-content>\u20101184 did not impair memory performance in the passive avoidance test or elicit significant catalepsy and only modestly inhibited spontaneous locomotor activity (<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>= 30\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>i.p.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ADN<\/jats:styled-content>\u20101184 combines antipsychotic\u2010like with antidepressant\u2010like properties without interfering with memory function or locomotion. This profile is better than that of commonly used atypical antipsychotics tested under the same conditions and suggests that it is feasible to identify drugs that improve BPSD, without exacerbating cognitive deficit or movement impairment, which are of particular concern in patients with dementia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12509","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T04:46:49Z","timestamp":1383799609000},"page":"973-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp>ADN<\/scp>\u20101184 a monoaminergic ligand with 5\u2010<scp>HT<\/scp><sub>6\/7<\/sub>receptor antagonist activity: pharmacological profile and potential therapeutic utility"],"prefix":"10.1111","volume":"171","author":[{"given":"M","family":"Ko\u0142aczkowski","sequence":"first","affiliation":[{"name":"Adamed Ltd Czosn\u00f3w Poland"},{"name":"Faculty of Pharmacy Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mierzejewski","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neurology Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bie\u0144kowski","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neurology Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Weso\u0142owska","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Newman\u2010Tancredi","sequence":"additional","affiliation":[{"name":"NeuroAct Communication Castres France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1521-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12444"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0022-3565(24)35047-5","article-title":"Characterization of MK\u2010801\u2010induced behavior as a putative rat model of psychosis","volume":"290","author":"Andin\u00e9 P","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1982.tb01032.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385902-0.00006-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2008.033.09.1236966"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.11.030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3280ae6c96"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020210"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1938-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1798-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00566.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2627-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000178415.22309.8f"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3282f62d8c"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.51"},{"key":"e_1_2_9_18_1","first-page":"1","article-title":"Lundbeck's Lu AE58054 meets primary endpoint in large placebo\u2010controlled clinical proof of concept study in people with Alzheimer's disease","volume":"472","author":"H. 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