{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:43:40Z","timestamp":1790318620527,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"\n Background and Purpose<\/jats:title>\n \n Azithromycin is a macrolide antibiotic with anti\u2010inflammatory and immunomodulating effects. Long\u2010term azithromycin therapy in patients with chronic lung diseases such as cystic fibrosis has been associated with increased antimicrobial resistance, emergence of hypermutable strains, ototoxicity and cardiac toxicity. The aim of this study was to assess the anti\u2010inflammatory effects of the non\u2010antibiotic azithromycin derivative\n CSY<\/jats:styled-content>\n 0073.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n We compared the effects of\n CSY<\/jats:styled-content>\n 0073 with those of azithromycin in experiments on bacterial cultures,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n seudomonas aeruginosa<\/jats:italic>\n biofilm, lung cells and mice challenged intranasally with\n \n P<\/jats:italic>\n <\/jats:styled-content>\n .\u2009aeruginosa<\/jats:italic>\n \u2005\n LPS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n In contrast to azithromycin,\n CSY<\/jats:styled-content>\n 0073 did not inhibit the growth of\n \n P<\/jats:italic>\n <\/jats:styled-content>\n .\u2009aeruginosa<\/jats:italic>\n ,\n \n S<\/jats:italic>\n <\/jats:styled-content>\n taphylococcus aureus<\/jats:italic>\n or\n \n H<\/jats:italic>\n <\/jats:styled-content>\n aemophilus influenzae<\/jats:italic>\n and had no effect on an established\n \n P<\/jats:italic>\n <\/jats:styled-content>\n .\u2009aeruginosa<\/jats:italic>\n biofilm. Bronchoalveolar lavage (\n BAL<\/jats:styled-content>\n ) fluids and lung homogenates collected after the\n LPS<\/jats:styled-content>\n challenge in mice showed that\n CSY<\/jats:styled-content>\n 0073 and azithromycin (200\u2009mg\u00b7kg\n \u22121<\/jats:sup>\n , i.p.) decreased neutrophil counts at 24\u2009h and\n TNF<\/jats:styled-content>\n \u2010\u03b1,\n CXCL<\/jats:styled-content>\n 1 and\n CXCL<\/jats:styled-content>\n 2 levels in the\n BAL<\/jats:styled-content>\n fluid after 3\u2009h and\n IL<\/jats:styled-content>\n \u20106,\n CXCL<\/jats:styled-content>\n 2 and\n IL<\/jats:styled-content>\n \u20101\u03b2 levels in the lung after 3\u2009h compared with the vehicle. However, only azithromycin reduced\n IL<\/jats:styled-content>\n \u20101\u03b2 levels in the lung 24\u2009h post\n LPS<\/jats:styled-content>\n challenge.\n CSY<\/jats:styled-content>\n 0073 and azithromycin similarly diminished the production of pro\u2010inflammatory cytokines by macrophages, but not lung epithelial cells, exposed to\n \n P<\/jats:italic>\n <\/jats:styled-content>\n .\u2009aeruginosa<\/jats:italic>\n \u2005\n LPS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Implications<\/jats:title>\n \n Unlike azithromycin,\n CSY<\/jats:styled-content>\n 0073 had no antibacterial effects but it did have a similar anti\u2010inflammatory profile to that of azithromycin. Hence,\n CSY<\/jats:styled-content>\n 0073 may have potential as a long\u2010term treatment for patients with chronic lung diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.12574","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T21:02:48Z","timestamp":1389646968000},"page":"1783-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Azithromycin analogue\n CSY<\/scp>\n 0073 attenuates lung inflammation induced by\n LPS<\/scp>\n challenge"],"prefix":"10.1111","volume":"171","author":[{"given":"V","family":"Balloy","sequence":"first","affiliation":[{"name":"INSERM UMR_S 938 CDR Saint\u2010Antoine Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 06, UMR_S 938, CDR Saint\u2010Antoine Paris France"},{"name":"Inserm U874 Paris France"},{"name":"Unit\u00e9 de d\u00e9fense Inn\u00e9e et Inflammation Institut Pasteur Paris 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