{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:41Z","timestamp":1791276341481,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2012-0172"],"award-info":[{"award-number":["6-2012-0172"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brain Korea 21 Project for Medical Science, Yonsei University"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","award":["NRF-2009-0092964"],"award-info":[{"award-number":["NRF-2009-0092964"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","award":["2010-0017984"],"award-info":[{"award-number":["2010-0017984"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background and Purpose<\/jats:title>\n \n Activation of hepatic stellate cells (\n HSCs<\/jats:styled-content>\n ) is a crucial step in the pathogenesis of hepatic fibrosis. Histone deacetylase (\n HDAC<\/jats:styled-content>\n ) is an attractive target in liver fibrosis because it plays a key role in gene expression and cell differentiation. We have developed a\n HDAC<\/jats:styled-content>\n inhibitor,\n N<\/jats:styled-content>\n \u2010hydroxy\u20107\u2010(2\u2010naphthylthio)heptanomide (\n HNHA<\/jats:styled-content>\n ), and investigated the anti\u2010fibrotic activity of\n HNHA<\/jats:styled-content>\n \u2005\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n We investigated the anti\u2010fibrotic effect of\n HNHA<\/jats:styled-content>\n on mouse and human\n HSC<\/jats:styled-content>\n activation\n in vitro<\/jats:italic>\n and in the liver of bile duct\u2010ligated (\n BDL<\/jats:styled-content>\n ) rats\n in vivo<\/jats:italic>\n using cell proliferation assays, cell cycle analysis, biochemical assay, immunohistochemistry and\n W<\/jats:styled-content>\n estern blots. Liver pathology was assessed with histochemical techniques.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n HNHA<\/jats:styled-content>\n inhibited proliferation and arrested the cell cycle via p21 induction in\n HSCs<\/jats:styled-content>\n . In addition,\n HNHA<\/jats:styled-content>\n induced apoptosis of\n HSCs<\/jats:styled-content>\n , which was correlated with reduced\n COX<\/jats:styled-content>\n \u20102 expression,\n NF<\/jats:styled-content>\n \u2010\u03ba\n B<\/jats:styled-content>\n activation and cell death signals.\n HNHA<\/jats:styled-content>\n restored liver function and decreased the accumulation of extracellular matrix in the liver via suppression of\n HSC<\/jats:styled-content>\n activation in\n BDL<\/jats:styled-content>\n rats\n in vivo<\/jats:italic>\n .\n HNHA<\/jats:styled-content>\n administration also increased survival in\n BDL<\/jats:styled-content>\n rats.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Implications<\/jats:title>\n \n HNHA<\/jats:styled-content>\n improved liver function, suppressed liver fibrosis and increased survival of\n BDL<\/jats:styled-content>\n rats, accompanied by reduction of cell growth, activation and survival of\n HSCs<\/jats:styled-content>\n . These findings show that\n HNHA<\/jats:styled-content>\n may be a potent anti\u2010fibrosis agent against hepatic fibrosis because of its multi\u2010targeted inhibition of\n HSC<\/jats:styled-content>\n activity\n in vivo<\/jats:italic>\n and\n in vitro<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.12590","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T06:14:48Z","timestamp":1390889688000},"page":"4820-4830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A new histone deacetylase inhibitor improves liver fibrosis in\n BDL<\/scp>\n rats through suppression of hepatic stellate cells"],"prefix":"10.1111","volume":"171","author":[{"given":"Ki Cheong","family":"Park","sequence":"first","affiliation":[{"name":"Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"},{"name":"Department of Surgery Yonsei University 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