{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:06:11Z","timestamp":1762866371929},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>We determined the effects of treatment with <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090, an inhibitor of advanced glycation end products, on the mechanical properties of the arterial system in streptozotocin (<jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>)\u2010induced diabetic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats, using aortic impedance analysis, and further investigated the effects of <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 on the progression of aortic pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>\u2010induced diabetic rats were treated with or without <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 (50\u2009mg <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content><jats:sup>\u20101<\/jats:sup> in drinking water) for 8 weeks and compared with control groups. Arterial <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> measurements, various metabolic parameters, aortic histopathology, collagen cross\u2010linking, <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content> accumulation, and <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content> protein expression in aortic tissue were determined. Pulsatile parameters were evaluated using a standard Fourier series expansion technique and impulse response function of the filtered aortic input impedance spectra.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 reduced glycated haemoglobin and triglycerides levels, although it had no effect on the glycaemic status. <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 did not affect arterial BP, but prevented the diabetes\u2010induced increase in peripheral resistance and variations in aortic distensibility, as it reduced aortic characteristic impedance by 21%. <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 also prevented the elevation in wave reflection factor, as indicated by a 22.5% reduction and an associated increase of 23.5% in wave transit time, suggesting it prevents the augmentation of the systolic load of the left ventricle. Moreover, <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 inhibited collagen cross\u2010linking and the accumulation of <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content> in the vasculature of diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\u201090 may impart significant protection against diabetes\u2010induced aortic stiffening and cardiac hypertrophy and provides an additional therapeutic option for treatment of <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content> associated diabetic complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12656","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T02:07:01Z","timestamp":1393380421000},"page":"3103-3114","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of a new advanced glycation inhibitor, <scp>LR<\/scp>\u201090, on mitigating arterial stiffening and improving arterial elasticity and compliance in a diabetic rat model: aortic impedance analysis"],"prefix":"10.1111","volume":"171","author":[{"given":"S","family":"Satheesan","sequence":"first","affiliation":[{"name":"Division of Comparative Medicine Beckman Research Institute City of Hope National Medical Center  Duarte CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Figarola","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism Beckman Research Institute City of 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