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The role of<jats:styled-content style=\"fixed-case\"><jats:roman>NO<\/jats:roman><\/jats:styled-content>in endothelial relaxation and erectile function is well accepted. The discovery of<jats:styled-content style=\"fixed-case\"><jats:roman>NO<\/jats:roman><\/jats:styled-content>as a small signalling gasotransmitter led to the investigation of the role of other endogenously derived gases, carbon monoxide (<jats:styled-content style=\"fixed-case\"><jats:roman>CO<\/jats:roman><\/jats:styled-content>) and hydrogen sulphide (<jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content>) in physiological and pathophysiological conditions. The role of<jats:styled-content style=\"fixed-case\"><jats:roman>NO<\/jats:roman><\/jats:styled-content>and<jats:styled-content style=\"fixed-case\"><jats:roman>CO<\/jats:roman><\/jats:styled-content>in sexual function and dysfunction has been investigated more extensively and, recently, the involvement of<jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>S<\/jats:roman><\/jats:styled-content>in erectile function has also been confirmed. In this review, we focus on the role of these three sister gasotransmitters in the physiology, pharmacology and pathophysiology of sexual function in man, specifically erectile function. We have also reviewed the role of soluble guanylyl cyclase\/c<jats:styled-content style=\"fixed-case\">GMP<\/jats:styled-content>pathway as a common target of these gasotransmitters. Several studies have proposed alternative therapies targeting different mechanisms in addition to<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>\u20105 inhibition for<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>treatment, since some patients do not respond to these drugs. This review highlights complementary and possible coordinated roles for these mediators and treatments targeting these gasotransmitters in erectile function\/<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue-6\">http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue-6<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12700","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T16:23:34Z","timestamp":1395678214000},"page":"1434-1454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Gas what:<scp><scp>NO<\/scp><\/scp>is not the only answer to sexual function"],"prefix":"10.1111","volume":"172","author":[{"given":"G","family":"Yetik\u2010Anacak","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of 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