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The review articles, written by a panel of distinguished experts, address the rapid progress in <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> channel research in fields as diverse as oncology, urology, dermatology, migraine, inflammation and pain. These reviews are complemented by original research reports focusing, among others, on the emerging roles of <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 in osteoporosis and cystitis and on evodiamine as a lead structure for the development of potent <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 agonists\/desensitizers. Other papers highlight the differences in <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>3 pharmacology between recombinant and native systems, the mechanisms of <jats:styled-content style=\"fixed-case\">TRPM<\/jats:styled-content>3 activation\/inhibition and <jats:styled-content style=\"fixed-case\">TRPP<\/jats:styled-content>2 as a target of naringenin, a dietary flavonoid with anticancer actions. New therapeutic opportunities in pain may arise from the strategy to combine <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content> channel and cell membrane impermeant sodium channel blockers to inhibit sensory nerve activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on the pharmacology of TRP channels. 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