{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:18:56Z","timestamp":1791231536034,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Background and Purpose<\/jats:title>Transient receptor potential vanilloid 1 (TRPV<\/jats:styled-content>1) and TRP<\/jats:styled-content> ankyrin 1 (TRPA<\/jats:styled-content>1) are involved in many biological processes, including nociception and hyperalgesia. Whereas the involvement of TRPV<\/jats:styled-content>1 in psychiatric disorders such as anxiety and depression has been reported, little is known regarding the role of TRPA<\/jats:styled-content>1 in these conditions.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>We investigated the role of TRPA<\/jats:styled-content>1 in mice models of depression [forced swimming test (FST<\/jats:styled-content>)] and anxiety [elevated plus maze (EPM) test<\/jats:styled-content>].<\/jats:p><\/jats:sec>Key Results<\/jats:title>Administration of the TRPA<\/jats:styled-content>1 antagonist (HC<\/jats:styled-content>030031, 30\u2009nmol in 2\u2009\u03bcL, i.c.v.) reduced immobility time in the FST<\/jats:styled-content>. Similar results were obtained after oral administration of HC<\/jats:styled-content>030031 (30\u2013300\u2009mg\u00b7kg\u22121<\/jats:sup>). The reduction in immobility time in FST<\/jats:styled-content> induced by HC<\/jats:styled-content>030031 (100\u2009mg\u00b7kg\u22121<\/jats:sup>) was completely prevented by pretreatment with TRPA<\/jats:styled-content>1 agonist, cinnamaldehyde (50\u2009mg\u00b7kg\u22121<\/jats:sup>, p.o.), which per se<\/jats:italic> was inactive. I<\/jats:styled-content>n the EPM<\/jats:styled-content> test, pretreatment with cinnamaldehyde (50\u2009mg\u00b7kg\u22121<\/jats:sup>, p.o.), which per se<\/jats:italic> did not affect behaviour response, prevented the anxiolytic\u2010like effect (increased open arm exploration) evoked by TRPA<\/jats:styled-content>1 blockade (HC<\/jats:styled-content>030031, 100\u2009mg\u00b7kg\u22121<\/jats:sup>, p.o.). Treatment with either cinnamaldehyde or HC<\/jats:styled-content>030031 did not affect spontaneous ambulation. Furthermore, TRPA<\/jats:styled-content>1\u2010deficient mice showed anxiolytic\u2010 and antidepressant\u2010like phenotypes in the FST<\/jats:styled-content> and EPM<\/jats:styled-content> test respectively.<\/jats:p><\/jats:sec>Conclusion and Implications<\/jats:title>The present findings indicate that genetic deletion or pharmacological blockade of TRPA<\/jats:styled-content>1 produces inhibitory activity in mouse models of anxiety and depression. These results imply that TRPA<\/jats:styled-content>1 exerts tonic control, promoting anxiety and depression, and that TRPA<\/jats:styled-content>1 antagonism has potential as an innovative strategy for the treatment of anxiety and mood disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12786","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T11:27:04Z","timestamp":1400671624000},"page":"4289-4299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The blockade of transient receptor potential ankirin 1 (TRPA<\/scp>1) signalling mediates antidepressant\u2010 and anxiolytic\u2010like actions in mice"],"prefix":"10.1111","volume":"171","author":[{"given":"Juliana Cavalcante","family":"de Moura","sequence":"first","affiliation":[{"name":"Department of Biophysics and Pharmacology Federal University of Rio Grande do Norte Natal RN 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