{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:56:12Z","timestamp":1777434972897,"version":"3.51.4"},"reference-count":226,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eating disorders, such as anorexia nervosa (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>), bulimia nervosa (<jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>) and binge eating disorders (<jats:styled-content style=\"fixed-case\">BED<\/jats:styled-content>), are described as abnormal eating habits that usually involve insufficient or excessive food intake. Animal models have been developed that provide insight into certain aspects of eating disorders. Several drugs have been found efficacious in these animal models and some of them have eventually proven useful in the treatment of eating disorders. This review will cover the role of monoaminergic neurotransmitters in eating disorders and their pharmacological manipulations in animal models and humans. Dopamine, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> (serotonin) and noradrenaline in hypothalamic and striatal regions regulate food intake by affecting hunger and satiety and by affecting rewarding and motivational aspects of feeding. Reduced neurotransmission by dopamine, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> and noradrenaline and compensatory changes, at least in dopamine D<jats:sub>2<\/jats:sub> and 5\u2010<jats:styled-content style=\"fixed-case\">HT<jats:sub>2C\/2A<\/jats:sub><\/jats:styled-content> receptors, have been related to the pathophysiology of <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> in humans and animal models. Also, in disorders and animal models of <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BED<\/jats:styled-content>, monoaminergic neurotransmission is down\u2010regulated but receptor level changes are different from those seen in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>. A hypofunctional dopamine system or overactive \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptors may contribute to an attenuated response to (palatable) food and result in hedonic binge eating. Evidence for the efficacy of monoaminergic treatments for <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> is limited, while more support exists for the treatment of <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BED<\/jats:styled-content> with monoaminergic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/bph.2014.171.issue-20\">http:\/\/dx.doi.org\/10.1111\/bph.2014.171.issue-20<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12789","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T10:19:46Z","timestamp":1401272386000},"page":"4767-4784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans"],"prefix":"10.1111","volume":"171","author":[{"given":"M A","family":"van Gestel","sequence":"first","affiliation":[{"name":"Brain Center Rudolf Magnus, Department of Translational Neuroscience University Medical Center Utrecht  Utrecht The 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