{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:13Z","timestamp":1790041273793,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["NSN C08-2254 and IP13-114"],"award-info":[{"award-number":["NSN C08-2254 and IP13-114"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Background and Purpose<\/jats:title>\n \n Hypertension is an important mediator of cardiac damage and remodelling. Hydrogen sulfide (\n \n \n H\n 2<\/jats:sub>\n S\n <\/jats:roman>\n <\/jats:styled-content>\n ) is an endogenously produced gasotransmitter with cardioprotective properties. However, it is not yet in clinical use. We, therefore, investigated the protective effects of sodium thiosulfate (\n STS<\/jats:styled-content>\n ), a clinically applicable\n \n \n H\n 2<\/jats:sub>\n S\n <\/jats:roman>\n <\/jats:styled-content>\n donor substance, in angiotensin\n II<\/jats:styled-content>\n (\n A<\/jats:styled-content>\n ng\n II<\/jats:styled-content>\n )\u2010induced hypertensive cardiac disease in rats.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n M<\/jats:styled-content>\n ale\n S<\/jats:styled-content>\n prague\n D<\/jats:styled-content>\n awley rats were infused with\n A<\/jats:styled-content>\n ng\n II<\/jats:styled-content>\n (435\u2009ng kg min\n \u22121<\/jats:sup>\n ) or saline (control) for 3 weeks via s.c. placed osmotic minipumps. During these 3 weeks, rats received i.p. injections of either\n STS<\/jats:styled-content>\n ,\n \n NaHS<\/jats:roman>\n <\/jats:styled-content>\n or vehicle (0.9%\n \n NaCl<\/jats:roman>\n <\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Compared with controls,\n A<\/jats:styled-content>\n ng\n II<\/jats:styled-content>\n infusion caused an increase in systolic and diastolic\n BP<\/jats:styled-content>\n with associated cardiac damage as evidenced by cardiac hypertrophy, an increase in atrial natriuretic peptide (\n ANP<\/jats:styled-content>\n ) m\n RNA<\/jats:styled-content>\n , cardiac fibrosis and increased oxidative stress. Treatment with\n \n NaHS<\/jats:roman>\n <\/jats:styled-content>\n and\n STS<\/jats:styled-content>\n prevented the development of hypertension and the increase in\n ANP<\/jats:styled-content>\n m\n RNA<\/jats:styled-content>\n levels. Furthermore, the degree of cardiac hypertrophy, the extent of histological fibrosis in combination with the expression of profibrotic genes and the levels of oxidative stress were all significantly decreased.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Implications<\/jats:title>\n \n A<\/jats:styled-content>\n ng\n II<\/jats:styled-content>\n \u2010induced hypertensive cardiac disease can be attenuated by treatment with\n STS<\/jats:styled-content>\n and\n \n NaHS<\/jats:roman>\n <\/jats:styled-content>\n . Although\n BP<\/jats:styled-content>\n regulation is the most plausible mechanism of cardiac protection, the antifibrotic and antioxidant properties of released sulfide may also contribute to their effects. Our data show that\n \n \n H\n 2<\/jats:sub>\n S\n <\/jats:roman>\n <\/jats:styled-content>\n might be a valuable addition to the already existing antihypertensive and cardioprotective therapies.\n <\/jats:p>\n <\/jats:sec>\n \n Linked Articles<\/jats:title>\n \n This article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit\n http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue\u20106<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.12825","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T16:57:36Z","timestamp":1403629056000},"page":"1494-1504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin\n II<\/scp>\n \u2010induced hypertensive heart disease in rats"],"prefix":"10.1111","volume":"172","author":[{"given":"P M","family":"Snijder","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A R","family":"Frenay","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pasch","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Clinical Pharmacology University Hospital Bern, Inselspital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Hillebrands","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H G D","family":"Leuvenink","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen Groningen The 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