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Dyskinesia can be reduced using compounds that act as direct or indirect agonists of the 5\u2010\n HT<\/jats:styled-content>\n 1<\/jats:sub>\n \n A<\/jats:sub>\n <\/jats:styled-content>\n receptor, but these drugs have been reported to worsen\n PD<\/jats:styled-content>\n features and are known to produce \u20185\u2010\n HT<\/jats:styled-content>\n syndrome\u2019, symptoms of which include tremor, myoclonus, rigidity and hyper\u2010reflexia.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n S<\/jats:styled-content>\n prague\u2010\n D<\/jats:styled-content>\n awley rats were given unilateral nigrostriatal dopamine lesions with 6\u2010hydroxydopamine. Each of the following three purportedly anti\u2010dyskinetic 5\u2010\n HT<\/jats:styled-content>\n compounds were administered 15\u2009min before\n L<\/jats:styled-content>\n \u2010\n DOPA<\/jats:styled-content>\n : the full 5\u2010\n HT<\/jats:styled-content>\n 1<\/jats:sub>\n \n A<\/jats:sub>\n <\/jats:styled-content>\n agonist \u00b1\u20108\u2010hydroxy\u20102\u2010dipropylaminotetralin (\u00b18\u2010\n OH<\/jats:styled-content>\n \u2010\n DPAT<\/jats:styled-content>\n ), the partial 5\u2010\n HT<\/jats:styled-content>\n 1<\/jats:sub>\n \n A<\/jats:sub>\n <\/jats:styled-content>\n agonist buspirone or the 5\u2010\n HT<\/jats:styled-content>\n transporter inhibitor citalopram. After these injections, animals were monitored for dyskinesia, 5\u2010\n HT<\/jats:styled-content>\n syndrome, motor activity and\n PD<\/jats:styled-content>\n akinesia.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Each 5\u2010\n HT<\/jats:styled-content>\n drug dose\u2010dependently reduced dyskinesia by relatively equal amounts (\u00b18\u2010\n OH<\/jats:styled-content>\n \u2010\n DPAT<\/jats:styled-content>\n \u2265 citalopram \u2265 buspirone), but 5\u2010\n HT<\/jats:styled-content>\n syndrome was higher with \u00b18\u2010\n OH<\/jats:styled-content>\n \u2010\n DPAT<\/jats:styled-content>\n , lower with buspirone and not present with citalopram. Importantly, with or without\n L<\/jats:styled-content>\n \u2010\n DOPA<\/jats:styled-content>\n , all three compounds provided an additional improvement of\n PD<\/jats:styled-content>\n akinesia. All drugs tempered the locomotor response to\n L<\/jats:styled-content>\n \u2010\n DOPA<\/jats:styled-content>\n suggesting dyskinesia reduction, but vertical rearing was reduced with 5\u2010\n HT<\/jats:styled-content>\n drugs, potentially reflecting features of 5\u2010\n HT<\/jats:styled-content>\n syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Implications<\/jats:title>\n \n The results suggest that compounds that indirectly facilitate 5\u2010\n HT<\/jats:styled-content>\n 1<\/jats:sub>\n \n A<\/jats:sub>\n <\/jats:styled-content>\n receptor activation, such as citalopram, may be more effective therapeutics than direct 5\u2010\n HT<\/jats:styled-content>\n 1<\/jats:sub>\n \n A<\/jats:sub>\n <\/jats:styled-content>\n receptor agonists because they exhibit similar anti\u2010dyskinesia efficacy, while possessing a reduced side effect profile.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.12894","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T04:27:30Z","timestamp":1409545650000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Side effect profile of 5\u2010\n HT<\/scp>\n treatments for\n P<\/scp>\n arkinson's disease and\n L<\/scp>\n \u2010\n DOPA<\/scp>\n \u2010induced dyskinesia in rats"],"prefix":"10.1111","volume":"172","author":[{"given":"D","family":"Lindenbach","sequence":"first","affiliation":[{"name":"Behavioral Neuroscience Program Department of Psychology Binghamton University \u2013 State University of New York Binghamton NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Behavioral Neuroscience Program Department of Psychology Binghamton University \u2013 State University of New York Binghamton NY 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