{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:07:49Z","timestamp":1792282069668,"version":"4.4.0"},"reference-count":90,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1002898"],"award-info":[{"award-number":["1002898"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Neglected tropical diseases are a group of some 17 diseases that afflict poor and predominantly rural people in developing nations. One significant disease that contributes to substantial morbidity in endemic areas is schistosomiasis, caused by infection with one of five species of blood fluke belonging to the trematode genus\n                      <jats:italic>Schistosoma<\/jats:italic>\n                      . Although there is one drug available for treatment of affected individuals in clinics, or for mass administration in endemic regions, there is a need for new therapies. A prominent target organ of schistosomes, either for drug or vaccine development, is the peculiar epithelial syncytium that forms the body wall (tegument) of this parasite. This dynamic layer is maintained and organized by concerted activity of a range of proteins, among which are the abundant tegumentary annexins. In this review, we will outline advances in structure\u2013function analyses of these annexins, as a means to understanding tegument cell biology in host\u2013parasite interaction and their potential exploitation as targets for anti\u2010schistosomiasis therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Annexins VII Programme. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue-7\">http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue\u20107<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.12898","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T04:29:26Z","timestamp":1409545766000},"page":"1653-1663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Structure\u2013function analysis of apical membrane\u2010associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control"],"prefix":"10.1111","volume":"172","author":[{"given":"Chiuan Yee","family":"Leow","sequence":"first","affiliation":[{"name":"School of Veterinary Science The University of Queensland  Gatton Queensland Australia"},{"name":"Infectious Diseases QIMR Berghofer Medical Research Institute  Herston Queensland Australia"},{"name":"Institute for Research in Molecular Medicine Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Willis","sequence":"additional","affiliation":[{"name":"Infectious Diseases QIMR Berghofer Medical Research Institute  Herston Queensland Australia"},{"name":"Structural Chemistry Program Eskitis Institute Griffith University  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Structural Chemistry Program Eskitis Institute Griffith University  Brisbane Queensland Australia"},{"name":"Faculty of Veterinary Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm K","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland  Gatton Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12444"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12450"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12451"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4269\/ajtmh.2008.78.929","article-title":"Artemether treatment of prepatent Schistosoma japonicum induces resistance to reinfection in association with reduced pathology","volume":"78","author":"Bartley PB","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4269\/ajtmh.2004.71.774","article-title":"Triggering of high\u2010level resistance against Schistosoma mansoni reinfection by artemether in the mouse model","volume":"71","author":"Bergquist R","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000244"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053300"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053294"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1270"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500287-MCP200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099004679"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01098.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02893"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000993"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.146.5.1655","article-title":"Comparison of Th1\u2010 and Th2\u2010associated immune reactivities stimulated by single versus multiple vaccination of mice with irradiated Schistosoma mansoni cercariae","volume":"146","author":"Caulada\u2010Benedetti Z","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2003.09.015"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(95)00026-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(00)01740-3"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00405.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009005939"},{"key":"e_1_2_11_22_1","unstructured":"DeLanoW(2002).The PyMOL molecular graphics system. 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