{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:54:14Z","timestamp":1791352454819,"version":"4.3.1"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BSV1-0030-01"],"award-info":[{"award-number":["ANR-12-BSV1-0030-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-JSV1-0001-01"],"award-info":[{"award-number":["ANR-12-JSV1-0001-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2012-StG-20111109"],"award-info":[{"award-number":["ERC-2012-StG-20111109"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["086867\/Z\/08\/Z"],"award-info":[{"award-number":["086867\/Z\/08\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Background and Purpose<\/jats:title>Long\u2010term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia\/reperfusion (I\/R<\/jats:styled-content>) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n\u20103 or n\u20106 polyunsaturated fatty acids (PUFA<\/jats:styled-content>) on intestinal I\/R<\/jats:styled-content>\u2010induced damage.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>Mice were fed three different isocaloric diets: a balanced diet used as a control and two different PUFA<\/jats:styled-content>\u2010enriched diets, providing either high levels of n\u20103 or of n\u20106 PUFA. Intestinal injury was evaluated after intestinal I\/R<\/jats:styled-content>. PUFA<\/jats:styled-content> metabolites were quantitated in intestinal tissues by LC\u2010MS\/MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Key Results<\/jats:title>In control diet\u2010fed mice, intestinal I\/R<\/jats:styled-content> caused inflammation and increased COX<\/jats:styled-content> and lipoxygenase\u2010derived metabolites compared with sham\u2010operated animals. Lipoxin A<\/jats:styled-content>4<\/jats:sub> (LxA4<\/jats:sub><\/jats:styled-content>) was significantly and selectively increased after ischaemia. Animals fed a high n\u20103 diet did not display a different inflammatory profile following intestinal I\/R<\/jats:styled-content> compared with control diet\u2010fed animals. In contrast, intestinal inflammation was decreased in the I\/R<\/jats:styled-content> group fed with high n\u20106 diet and level of LxA4<\/jats:sub><\/jats:styled-content> was increased post\u2010ischaemia compared with control diet\u2010fed mice. Blockade of the LxA4<\/jats:sub><\/jats:styled-content> receptor (Fpr2<\/jats:styled-content>), prevented the anti\u2010inflammatory effects associated with the n\u20106 rich diet.<\/jats:p><\/jats:sec>Conclusions and Implications<\/jats:title>This study indicates that high levels of dietary n\u20106, but not n\u20103, PUFAs<\/jats:styled-content> provides significant protection against intestinal I\/R<\/jats:styled-content>\u2010induced damage and demonstrates that the endogenous production of LxA4<\/jats:sub><\/jats:styled-content> can be influenced by diet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.12957","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T02:37:20Z","timestamp":1412822240000},"page":"910-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Protective effects of n\u20106 fatty acids\u2010enriched diet on intestinal ischaemia\/reperfusion injury involve lipoxin A<\/scp>4<\/sub> and its receptor"],"prefix":"10.1111","volume":"172","author":[{"given":"T","family":"Gobbetti","sequence":"first","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"WHRI Queen Mary University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ducheix","sequence":"additional","affiliation":[{"name":"UMR1331, Toxalim Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"le Faouder","sequence":"additional","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Lipidomic Core Facility Metatoul Platform Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Inserm U1048 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Perez","sequence":"additional","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Riols","sequence":"additional","affiliation":[{"name":"Lipidomic Core Facility Metatoul Platform Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Inserm U1048 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Boue","sequence":"additional","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bertrand\u2010Michel","sequence":"additional","affiliation":[{"name":"Lipidomic Core Facility Metatoul Platform Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"},{"name":"Inserm U1048 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dubourdeau","sequence":"additional","affiliation":[{"name":"Ambiotis SAS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Guillou","sequence":"additional","affiliation":[{"name":"UMR1331, Toxalim Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Perretti","sequence":"additional","affiliation":[{"name":"WHRI Queen Mary University London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Vergnolle","sequence":"additional","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cenac","sequence":"additional","affiliation":[{"name":"Inserm, U1043 Toulouse France"},{"name":"CNRS, U5282 Toulouse France"},{"name":"Centre de Physiopathologie de Toulouse Purpan (CPTP) Universit\u00e9 de Toulouse Universit\u00e9 Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12451"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12445"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705912"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.02.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003335"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-496661"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199810000-00005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051098"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502005000400013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1008153"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41982-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2008.09.019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.04.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1339"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5260"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.09.031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075581"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1663"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2772"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1285"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05637"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00507.2001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.159046"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(02)00564-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.06.014"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116738"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180332ca5"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3727"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2005.10.004"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00873.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01771-5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.10.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004212"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.11.1445"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1143"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2470"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm786"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.02.006"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(89)90264-6"},{"key":"e_1_2_10_47_1","first-page":"1","article-title":"Lipoxins: a new series of eicosanoids (biosynthesis, stereochemistry, and biological activities)","volume":"229","author":"Serhan CN","year":"1988","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1276"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5335"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151409"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2009.09.004"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1693"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0727-x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152806776383116"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9620-5"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001578"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-152298"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.12957","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.12957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:48:13Z","timestamp":1696344493000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.12957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/bph.12957"],"URL":"https:\/\/doi.org\/10.1111\/bph.12957","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]},"assertion":[{"value":"2014-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}