{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:10:21Z","timestamp":1780924221143,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"\n Background and Purpose<\/jats:title>\n \n In the search for safer and effective anti\u2010inflammatory agents, we investigated the effect of methyl indoline\u20103\u2010propionate and indoline\u20103\u2010(3\u2010aminopropyl) carbamates on\n LPS<\/jats:styled-content>\n \u2010induced lung injury and pro\u2010inflammatory cytokines in mice. Their mechanism of action was determined in murine peritoneal macrophages.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n Lung injury was induced by intratracheal infusion of\n LPS<\/jats:styled-content>\n and assessed by the change in lung weight and structure by light microscopy after staining by haematoxylin and eosin. In\n LPS<\/jats:styled-content>\n \u2010activated macrophages,\n MAPK<\/jats:styled-content>\n proteins and\n I<\/jats:styled-content>\n \u03ba\n B\u03b1<\/jats:styled-content>\n were measured by\n W<\/jats:styled-content>\n estern blotting and the transcription factors,\n AP<\/jats:styled-content>\n \u20101 and\n NF<\/jats:styled-content>\n \u2010\n \u03baB<\/jats:styled-content>\n by electromobility shift assay. Cytokines in the plasma and spleen of mice injected with\n LPS<\/jats:styled-content>\n were measured by\n elisa<\/jats:sc>\n \u2010based assay.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n AN<\/jats:styled-content>\n 917 and\n AN<\/jats:styled-content>\n 680 (1\u201310\u2009pM) decreased\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:styled-content>\n protein in macrophages by inhibiting phosphorylation of p38\n MAPK<\/jats:styled-content>\n ,\n I\u03baB\u03b1<\/jats:styled-content>\n degradation and activation of\n AP<\/jats:styled-content>\n \u20101 and\n NF<\/jats:styled-content>\n \u2010\n \u03baB<\/jats:styled-content>\n without affecting cell viability. In vivo, these compounds (10\u2009\n \u03bc<\/jats:styled-content>\n mol\u00b7kg\n \u22121<\/jats:sup>\n ) markedly decreased lung injury induced by\n LPS<\/jats:styled-content>\n and the elevation of\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:styled-content>\n and\n IL<\/jats:styled-content>\n \u20106 in lung, plasma and spleen. Activation of\n \u03b1<\/jats:styled-content>\n \u20107n\n ACh<\/jats:styled-content>\n receptors contributed to the reduction of\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:styled-content>\n by\n AN<\/jats:styled-content>\n 917, which inhibited\n AChE<\/jats:styled-content>\n in the spleen by 35%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion and Implications<\/jats:title>\n \n Indoline carbamates are potent inhibitors of pro\u2010inflammatory mediators in murine macrophages and in mice injected with\n LPS<\/jats:styled-content>\n , acting via the p38\n MAPK<\/jats:styled-content>\n ,\n AP<\/jats:styled-content>\n \u20101 and\n NF<\/jats:styled-content>\n \u2010\n \u03baB<\/jats:styled-content>\n cascades. Indirect\n \u03b1<\/jats:styled-content>\n \u20107\n nACh<\/jats:styled-content>\n receptor activation by\n AN<\/jats:styled-content>\n 917, through inhibition of\n AChE<\/jats:styled-content>\n , contributes to its anti\u2010inflammatory effect. Indoline carbamates may have therapeutic potential for lung injury and other diseases associated with chronic inflammation without causing immunosuppression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.12982","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T05:04:46Z","timestamp":1413522286000},"page":"1101-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Indoline\u20103\u2010propionate and 3\u2010aminopropyl carbamates reduce lung injury and pro\u2010inflammatory cytokines induced in mice by\n LPS<\/scp>"],"prefix":"10.1111","volume":"172","author":[{"given":"E","family":"Finkin\u2010Groner","sequence":"first","affiliation":[{"name":"Institute of Drug Research The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Moradov","sequence":"additional","affiliation":[{"name":"Institute of Drug Research The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Shifrin","sequence":"additional","affiliation":[{"name":"Institute of Drug Research The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bejar","sequence":"additional","affiliation":[{"name":"Institute of Drug Research The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nudelman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bar Ilan University Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Institute of Drug Research The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.034"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12451"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12446"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050488"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2275"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.3.618.618"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes413"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215840110"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945012800399008"},{"key":"e_1_2_9_11_1","unstructured":"Finkin\u2010GronerE(2013).Novel multi\u2010functional drugs for the treatment of neurodegenerative diseases. 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