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Dietary fish oil (\n                      <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content>\n                      ), containing\n                      <jats:styled-content style=\"fixed-case\">\u03c9<\/jats:styled-content>\n                      3 polyunsaturated fatty acids (\n                      <jats:styled-content style=\"fixed-case\">PUFAs<\/jats:styled-content>\n                      ), has anti\u2010inflammatory and cardio\u2010protective properties, such as lowering cholesterol and modulating platelet activity. The objective of the present study was to investigate the potential additional effects of aspirin and\n                      <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content>\n                      on platelet activity and vascular response to injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Femoral arterial remodelling was induced by wire injury in mice. Platelet aggregation, and photochemical\u2010 and ferric chloride\u2010induced carotid artery thrombosis were employed to evaluate platelet function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>FO treatment increased membrane \u03c93 PUFA incorporation, lowered plasma triglyceride and cholesterol levels, and reduced systolic BP in mice. FO or aspirin alone inhibited platelet aggregation; however, when combined, they exhibited synergistic suppression of platelet activity in mice, independent of COX\u20101 inhibition. FO alone, but not aspirin, attenuated arterial neointimal growth in response to injury. Strikingly, a combination of FO and aspirin synergistically inhibited injury\u2010induced neointimal hyperplasia and reduced perivascular inflammatory reactions. Moreover, co\u2010administration of FO and aspirin decreased the expression of pro\u2010inflammatory cytokines and adhesion molecules in inflammatory cells. Consistently, a pro\u2010resolution lipid mediator\u2010Resolvin E1, was significantly elevated in plasma in FO\/aspirin\u2010treated mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>\n                      Co\u2010administration of\n                      <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content>\n                      and low\u2010dose aspirin may act synergistically to protect against thrombosis and injury\u2010induced vascular remodelling in mice. Our results support further investigation of adjuvant\n                      <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content>\n                      supplementation for patients with stable coronary artery disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Chinese Innovation in Cardiovascular Drug Discovery. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue-23\">http:\/\/dx.doi.org\/10.1111\/bph.2015.172.issue-23<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.12986","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T00:28:58Z","timestamp":1414024138000},"page":"5647-5660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Aspirin enhances protective effect of fish oil against thrombosis and injury\u2010induced vascular remodelling"],"prefix":"10.1111","volume":"172","author":[{"given":"Yanjun","family":"Gong","sequence":"first","affiliation":[{"name":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences Chinese 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