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Immunocytochemical evidence suggests their presence in this brain region. Therefore, we aimed to verify their existence, pharmacological properties and function in regulating activity in neurons of the ventrobasal thalamus (<jats:styled-content style=\"fixed-case\">VB<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Characterization of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content><jats:sub>v<\/jats:sub>7 channels was performed by combining <jats:italic>in vitro<\/jats:italic>, <jats:italic>in vivo<\/jats:italic> and <jats:italic>in silico<\/jats:italic> techniques with a pharmacological approach. Retigabine (30\u2009\u03bcM) and XE991 (20\u2009\u03bcM), a specific <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content><jats:sub>v<\/jats:sub>7 channel enhancer and blocker, respectively, were applied in acute brain slices during electrophysiological recordings. The effects of intrathalamic injection of retigabine (3\u2009mM, 300\u2009nL) and\/or <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>991 (2\u2009mM, 300\u2009nL) were investigated in freely moving animals during hot\u2010plate tests by recording behaviour and neuronal activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>K<jats:sub>v<\/jats:sub>7.2 and K<jats:sub>v<\/jats:sub>7.3 subunits were found to be abundantly expressed in TC neurons of mouse VB. A slow <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content><jats:sup>+<\/jats:sup>\u2010current with properties of <jats:styled-content style=\"fixed-case\"><jats:italic>I<\/jats:italic><jats:sub>M<\/jats:sub><\/jats:styled-content> was activated by retigabine and inhibited by <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>991. K<jats:sub>v<\/jats:sub>7 channel activation evoked membrane hyperpolarization, a reduction in tonic action potential firing, and increased burst firing <jats:italic>in vitro<\/jats:italic> and in computational models. Single\u2010unit recordings and pharmacological intervention demonstrated a specific burst\u2010firing increase upon <jats:styled-content style=\"fixed-case\"><jats:italic>I<\/jats:italic><jats:sub>M<\/jats:sub><\/jats:styled-content> activation <jats:italic>in vivo<\/jats:italic>. A <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content><jats:sub>v<\/jats:sub>7 channel\u2010mediated increase in pain threshold was associated with fewer <jats:styled-content style=\"fixed-case\">VB<\/jats:styled-content> units responding to noxious stimuli, and increased burst firing in responsive neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content><jats:sub>v<\/jats:sub>7 channel enhancement alters somatosensory activity and may reflect an anti\u2010nociceptive mechanism during acute pain processing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13113","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:30:07Z","timestamp":1423823407000},"page":"3126-3140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Thalamic <scp>K<\/scp><sub>v<\/sub>7 channels: pharmacological properties and activity control during noxious signal processing"],"prefix":"10.1111","volume":"172","author":[{"given":"Manuela","family":"Cerina","sequence":"first","affiliation":[{"name":"Institute of Physiology I Westf\u00e4lische Wilhelms\u2010University  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna J","family":"Szkudlarek","sequence":"additional","affiliation":[{"name":"Institute of Physiology I Westf\u00e4lische Wilhelms\u2010University  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Coulon","sequence":"additional","affiliation":[{"name":"Institute of Physiology I Westf\u00e4lische Wilhelms\u2010University  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Meuth","sequence":"additional","affiliation":[{"name":"Institute of Physiology I Westf\u00e4lische Wilhelms\u2010University  M\u00fcnster 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