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However, EGCG<\/jats:styled-content> has limited clinical application, which necessitates the development of a more effective EGCG<\/jats:styled-content> prodrug as an anticancer agent.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>Derivatives of EGCG<\/jats:styled-content> were evaluated for their stability and anti\u2010tumour activity in human chronic myeloid leukaemia (CML<\/jats:styled-content>) K<\/jats:styled-content>562 and KBM5<\/jats:styled-content> cells.<\/jats:p><\/jats:sec>Key Results<\/jats:title>EGCG<\/jats:styled-content>\u2010mono\u2010palmitate (EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content>) showed most prolonged stability compared with other EGCG<\/jats:styled-content> derivatives. EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> exerted greater cytotoxicity and apoptosis in K<\/jats:styled-content>562 and KBM5<\/jats:styled-content> cells than the other EGCG<\/jats:styled-content> derivatives. EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> induced S<\/jats:styled-content>rc\u2010homology 2 domain\u2010containing tyrosine phosphatase 1 (SHP<\/jats:styled-content>\u20101) leading decreased oncogenic protein BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content> and STAT3<\/jats:styled-content> phosphorylation in CML<\/jats:styled-content> cells, compared with treatment with EGCG<\/jats:styled-content>. Furthermore, EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> reduced phosphorylation of STAT3<\/jats:styled-content> and survival genes in K<\/jats:styled-content>562 cells, compared with EGCG<\/jats:styled-content>. Conversely, depletion of SHP<\/jats:styled-content>\u20101 or application of the tyrosine phosphatase inhibitor pervanadate blocked the ability of EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> to suppress phosphorylation of BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content> and STAT3<\/jats:styled-content>, and the expression of survival genes downstream of STAT3<\/jats:styled-content>. In addition, EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> treatment more effectively suppressed tumour growth in BALB<\/jats:styled-content>\/c athymic nude mice compared with untreated controls or EGCG<\/jats:styled-content> treatment. Immunohistochemistry revealed increased caspase 3 and SHP<\/jats:styled-content>\u20101 activity and decreased phosphorylation of BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content> in the EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content>\u2010treated group relative to that in the EGCG<\/jats:styled-content>\u2010treated group.<\/jats:p><\/jats:sec>Conclusions and Implications<\/jats:title>EGCG<\/jats:styled-content>\u2010MP<\/jats:styled-content> induced SHP<\/jats:styled-content>\u20101\u2010mediated inhibition of BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content> and STAT3<\/jats:styled-content> signalling in vitro<\/jats:italic> and in vivo<\/jats:italic> more effectively than EGCG.<\/jats:styled-content> This derivative may be a potent chemotherapeutic agent for CML<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13146","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T13:36:08Z","timestamp":1427895368000},"page":"3565-3578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A derivative of epigallocatechin\u20103\u2010gallate induces apoptosis via SHP<\/scp>\u20101\u2010mediated suppression of BCR\u2010ABL<\/scp> and STAT3<\/scp> signalling in chronic myelogenous leukaemia"],"prefix":"10.1111","volume":"172","author":[{"given":"Ji Hoon","family":"Jung","sequence":"first","affiliation":[{"name":"College of Korean Medicine Kyung Hee University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyong","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Kyung Hee University Seoul South 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