{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T05:40:25Z","timestamp":1771738825303,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DFG","award":["KR 1152-3-1"],"award-info":[{"award-number":["KR 1152-3-1"]}]},{"name":"DFG","award":["SCHU 2604\/1-1"],"award-info":[{"award-number":["SCHU 2604\/1-1"]}]},{"name":"DFG","award":["SAF2011-25303"],"award-info":[{"award-number":["SAF2011-25303"]}]},{"name":"DFG","award":["GR921641"],"award-info":[{"award-number":["GR921641"]}]},{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>unich <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>r\u00f6mter (<jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content>) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffness and\/or vascular remodelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Experiments were performed in mesenteric arteries from 12\u2010week\u2010old <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>yoto (<jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>) and consomic <jats:styled-content style=\"fixed-case\">MWF\u20106<jats:sup>SHR<\/jats:sup><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MWF\u20108<jats:sup>SHR<\/jats:sup><\/jats:styled-content> rats in which chromosomes 6 or 8 associated with albuminuria from <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> were replaced by the respective chromosome from spontaneously hypertensive rats (SHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Incremental distensibility, wall stress and strain were reduced, and arterial stiffness was significantly increased in albuminuric <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>. Albuminuria suppression in both consomic strains was associated with lower \u03b2\u2010values in <jats:styled-content style=\"fixed-case\">MWF\u20108<jats:sup>SHR<\/jats:sup><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MWF\u20106<jats:sup>SHR<\/jats:sup><\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content>. Moreover, elastin content was significantly lower in <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> external elastic lamina compared with <jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content> and both consomic strains. In addition, a reduction in arterial external and internal diameter and cross\u2010sectional area was detected in <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>, thus exhibiting an inward hypotrophic remodelling. However, these alterations remained unchanged in both consomic strains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>These data demonstrate that albuminuria in <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> is associated with increased arterial stiffness due to a reduction of elastin content in the external elastic lamina. Moreover, inward hypotrophic remodelling in <jats:styled-content style=\"fixed-case\">MWF<\/jats:styled-content> is not directly associated with albuminuria. In contrast, we demonstrated that two major genetic loci affect both the development of albuminuria and arterial stiffness, thus linking albuminuria and impairment of mechanical properties of resistance arteries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13223","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T09:55:30Z","timestamp":1434362130000},"page":"4406-4418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin"],"prefix":"10.1111","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-8214","authenticated-orcid":false,"given":"M","family":"Gil\u2010Ortega","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud Facultad de Farmacia Universidad CEU \u2013 San Pablo  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C F","family":"Garc\u00eda\u2010Prieto","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud Facultad de Farmacia Universidad CEU \u2013 San Pablo  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ruiz\u2010Hurtado","sequence":"additional","affiliation":[{"name":"Instituto Pluridisciplinar and Facultad de Farmacia Universidad Complutense  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n imas12 Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Steireif","sequence":"additional","affiliation":[{"name":"Instituto Pluridisciplinar and Facultad de Farmacia Universidad Complutense  Madrid Spain"},{"name":"Department of Clinical Pharmacology and Toxicology Charit\u00e9 \u2013 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology Charit\u00e9 \u2013 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Toxicology Charit\u00e9 \u2013 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Fern\u00e1ndez\u2010Alfonso","sequence":"additional","affiliation":[{"name":"Instituto Pluridisciplinar and Facultad de Farmacia Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Arribas","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Somoza","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud Facultad de Farmacia Universidad CEU \u2013 San Pablo  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12451"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12445"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00155.2008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000456"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.046904"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834d9e0f"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00886.2010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285287"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283331e50"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.2.397"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1681\/ASN.V981399","article-title":"Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit","volume":"9","author":"Fassi A","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00833.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02361.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32833e4ce1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095312"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.030056"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01262.2005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070361"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00431.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.07.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.177469"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006111217"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f50066"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2598"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2267"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.77"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834b5627"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.471"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-37"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018060-00017"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000023"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00873.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.959817"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080895"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01338.x"},{"key":"e_1_2_10_40_1","first-page":"505","article-title":"Vascular remodeling","volume":"28","author":"Mulvany MJ","year":"1996","journal-title":"Hypertension"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832b4740"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1143"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl733"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000292"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0646-y"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678342"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328356a60a"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.77"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000031803.55613.86"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000100126.62370.25"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030206"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.90270.2008"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00123.2011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834a4d38"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.09.008"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090769"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283642384"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0242-4"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.12.016"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000218062"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.100540"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0202.101970"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00752.x"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.13223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:35:31Z","timestamp":1696361731000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.13223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":62,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/bph.13223"],"URL":"https:\/\/doi.org\/10.1111\/bph.13223","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]},"assertion":[{"value":"2014-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}