{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:38:30Z","timestamp":1784864310900,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tourette Syndrome Association"},{"name":"Kansas Strategic Initiative Grant"},{"name":"NIH","award":["R01 MH104603"],"award-info":[{"award-number":["R01 MH104603"]}]},{"name":"NIH","award":["P20 GM103638"],"award-info":[{"award-number":["P20 GM103638"]}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Background and Purpose<\/jats:title>Sensorimotor gating is a perceptual process aimed at filtering out irrelevant information. In humans and animal models, this function can be operationally measured through the prepulse inhibition (PPI<\/jats:styled-content>) of the acoustic startle reflex. Notably,PPI<\/jats:styled-content>deficits are associated with numerous neuropsychiatric conditions characterized by gating disturbances, including schizophrenia andT<\/jats:styled-content>ourette syndrome. Ample evidence has shown that dopamine plays a key role inPPI<\/jats:styled-content>regulation and, in particular, rodent studies indicate that this neurotransmitter modulatesPPI<\/jats:styled-content>throughD<\/jats:styled-content>1<\/jats:sub>andD<\/jats:styled-content>2<\/jats:sub>dopamine receptors. In mice, the relative contributions of these two families of receptors are strain\u2010dependent. Conversely, the role ofD<\/jats:styled-content>1<\/jats:sub>receptors in the regulation ofPPI<\/jats:styled-content>across different rat strains remains unclear.<\/jats:p><\/jats:sec>Experimental Approach<\/jats:title>We tested the effects of selectiveD<\/jats:styled-content>1<\/jats:sub>andD<\/jats:styled-content>2<\/jats:sub>receptor agonists and antagonists on the startle reflex andPPI<\/jats:styled-content>ofS<\/jats:styled-content>prague\u2010D<\/jats:styled-content>awley,W<\/jats:styled-content>istar andL<\/jats:styled-content>ong\u2013E<\/jats:styled-content>vans rats.<\/jats:p><\/jats:sec>Key Results<\/jats:title>I<\/jats:styled-content>n contrast withS<\/jats:styled-content>prague\u2010D<\/jats:styled-content>awley andW<\/jats:styled-content>istar rats, the fullD<\/jats:styled-content>1<\/jats:sub>receptor agonistSKF<\/jats:styled-content>82958 elicited significantPPI<\/jats:styled-content>deficits inL<\/jats:styled-content>ong\u2013E<\/jats:styled-content>vans rats, an effect sensitive to the selectiveD<\/jats:styled-content>1 antagonistSCH<\/jats:styled-content>23390.<\/jats:p><\/jats:sec>Conclusions and Implications<\/jats:title>Our results suggest that, inL<\/jats:styled-content>ong\u2013E<\/jats:styled-content>vans rats,D<\/jats:styled-content>1<\/jats:sub>receptor activation may be sufficient to significantly impairPPI<\/jats:styled-content>. These data emphasize the role ofD<\/jats:styled-content>1<\/jats:sub>receptors in the pathophysiology of neuropsychiatric disorders featuring alterations in sensorimotor gating, and uphold the importance of the genetic background in shaping the role of dopamine receptors in the regulation of this key information\u2010processing function.<\/jats:p><\/jats:sec>Linked Articles<\/jats:title>This article is part of a themed section on Updating Neuropathology and Neuropharmacology of Monoaminergic Systems. To view the other articles in this section visithttp:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v173.13\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13232","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T11:22:04Z","timestamp":1435058524000},"page":"2122-2134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Selective activation ofD<\/scp>1<\/sub>dopamine receptors impairs sensorimotor gating inL<\/scp>ong\u2013E<\/scp>vans rats"],"prefix":"10.1111","volume":"173","author":[{"given":"Laura J","family":"Mosher","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology School of Pharmacy University of Kansas Lawrence KS USA"},{"name":"Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA) University of Kansas Lawrence KS USA"},{"name":"Problem Gambling Research Studies (ProGResS) Network University of Kansas Lawrence KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Frau","sequence":"additional","affiliation":[{"name":"\u2018Guy Everett\u2019 Laboratory, Dept. of Neuroscience \u2018B.B. Brodie\u2019 University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pardu","sequence":"additional","affiliation":[{"name":"\u2018Guy Everett\u2019 Laboratory, Dept. of Neuroscience \u2018B.B. Brodie\u2019 University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Pes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology School of Pharmacy University of Kansas Lawrence KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Devoto","sequence":"additional","affiliation":[{"name":"\u2018Guy Everett\u2019 Laboratory, Dept. of Neuroscience \u2018B.B. 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