{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:36:33Z","timestamp":1772537793352,"version":"3.50.1"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Cardiac hypertrophy is a mechanism to compensate for increased cardiac work load, that is, after myocardial infarction or upon pressure overload. However, in the long run cardiac hypertrophy is a prevailing risk factor for the development of heart failure. During pathological remodelling processes leading to heart failure, decompensated hypertrophy, death of cardiomyocytes by apoptosis or necroptosis and fibrosis as well as a progressive dysfunction of cardiomyocytes are apparent. Interestingly, the induction of hypertrophy, cell death or fibrosis is mediated by similar signalling pathways. Therefore, tiny changes in the signalling cascade are able to switch physiological cardiac remodelling to the development of heart failure. In the present review, we will describe examples of these molecular switches that change compensated hypertrophy to the development of heart failure and will focus on the importance of the signalling cascades of the TGF\u03b2 superfamily in this process. In this context, potential therapeutic targets for pharmacological interventions that could attenuate the progression of heart failure will be discussed.<\/jats:p>","DOI":"10.1111\/bph.13344","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T22:34:46Z","timestamp":1443825286000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Molecular switches under TGF\u03b2 signalling during progression from cardiac hypertrophy to heart failure"],"prefix":"10.1111","volume":"173","author":[{"given":"J","family":"Heger","sequence":"first","affiliation":[{"name":"Institute of Physiology Justus Liebig University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institute of Physiology Justus Liebig University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Euler","sequence":"additional","affiliation":[{"name":"Institute of Physiology Justus Liebig University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.106"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12445"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12449"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12450"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12451"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70577"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(92)93381-S"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02043"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90665-3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608867200"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304185"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.1.23"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.883843"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.550624"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/\u00a0CIRCRESAHA.\u00a0112.265942"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710228105"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/\u00a0CIRCRESAHA.\u00a0114.300559"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES81.6.1021"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.769984"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096820"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.580"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637827"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70014-3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00329.2006"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.11.017"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.222364"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.08.008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0149OC"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.7.1743"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00377-1"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.5.5522"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21805"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.04.013"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu409"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt094"},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","unstructured":"HoppeUC ErdmannE(2009).Kapitel 5 Chronische Herzinsuffizienz aus Erdmann E. Klinische Kardiologie. Krankheiten des Herzens des Kreislaufs und herznaher Gef\u00e4\u00dfe. 7. Auflage Springer Verlag","DOI":"10.1007\/978-3-540-79011-2"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.46"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300682"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.244442"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026628"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.07.017"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/\u00a0j.cbi.2014.11.017"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0511"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.09.013"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr071"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.234286"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001469"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/\u00a0jcs.02587"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011195"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/Cr.2014.9"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034049.61181"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3032"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141224726"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.202176"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.114"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.030932"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610173351603"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1143"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0524-6"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.109868"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.10.023"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.013847"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00578.2001"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.04.030"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.01.023"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2837"},{"issue":"5","key":"e_1_2_12_71_1","doi-asserted-by":"crossref","first-page":"C1311","DOI":"10.1152\/ajpcell.1995.269.5.C1311","article-title":"Induction of hypertrophic responsiveness to isoproterenol by TGF\u2010beta in adult rat cardiomyocytes","volume":"269","author":"Schl\u00fcter KD","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.02.021"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6139"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0090-0"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00741.2003"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07511"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45938"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu184"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6289-5"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13073"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.643296"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000185833.42544.06"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.040584"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.05.010"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66339"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/75037"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.328"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1083OC"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.13344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:07:15Z","timestamp":1696302435000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.13344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,16]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/bph.13344"],"URL":"https:\/\/doi.org\/10.1111\/bph.13344","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,16]]},"assertion":[{"value":"2015-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}