{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:06:56Z","timestamp":1790870816549,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270303, 81470516, 81470402"],"award-info":[{"award-number":["81270303, 81470516, 81470402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Activation of glucagon\u2010like peptide\u20101 (GLP\u20101) receptor exerts a range of cardioprotective effects. Geniposide is an agonist of GLP\u20101 receptor, but its role in cardiac hypertrophy remains completely unknown. Here, we have investigated its protective effects and clarified the underlying molecular mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>The transverse aorta was constricted in C57\/B6 mice and then geniposide was given orally for 7\u00a0weeks. Morphological changes, echocardiographic parameters, histological analyses and hypertrophic markers were used to evaluate hypertrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Geniposide inhibited the hypertrophic response induced by constriction of the transverse aorta or by isoprenaline. Activation of 5\u2032\u2010AMP\u2010activated protein kinase\u2010\u03b1 (AMPK\u03b1) and inhibition of mammalian target of rapamycin, ERK and endoplasmic reticulum stress were observed in hypertrophic hearts that were treated with geniposide. Furthermore, Compound C (CpC) or knock\u2010down of AMPK\u03b1 restricted protection of geniposide against cell hypertrophy and activation of mammalian target of rapamycin and ERK induced by hypertrophic stimuli. CpC or shAMPK\u03b1 also abolished the protection of geniposide against endoplasmic reticulum stress induced by thapsigargin or dihtiothreitol. The cardio\u2010protective effects of geniposide were ablated in mice subjected to CpC. GLP\u20101receptor blockade counteracted the anti\u2010hypertrophic response and activation of AMPK\u03b1 by geniposide. Knock\u2010down of GLP\u20101 receptor also offset the inhibitory effects of geniposide on cardiac hypertrophy <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>Geniposide protected against cardiac hypertrophy via activation of the GLP\u20101 receptor\/AMPK\u03b1 pathway. Geniposide is a potential therapeutic drug for cardiac hypertrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13449","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T14:30:03Z","timestamp":1454596203000},"page":"1502-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Protection against cardiac hypertrophy by geniposide involves the GLP\u20101 receptor \/ AMPK\u03b1 signalling pathway"],"prefix":"10.1111","volume":"173","author":[{"given":"Zhen\u2010Guo","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Cardiovascular Research Institute of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan 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