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Nutraceuticals have been proposed as key tools for the prevention and cure of some pathological conditions. This is leading research to develop new formulations based on these pharma\u2010foods addressed in a specific way to prevent and cure health issues, which, in turn, will have an effect on therapy\u2010related costs sustained by any National Health Organization. According to existing regulations, nutraceuticals cannot be categorized as either food or drugs but, by definition, often inhabit a grey area in between the two, being assimilated into food supplements, notwithstanding the beneficial properties that they can provide for some pathological conditions. A nutraceuticals\u2010based approach for health management, in particular for some pathological conditions, has resulted in a worldwide growing \u2018nutraceutical\u2019 revolution. An outstanding example is the approach to the \u2018metabolic syndrome\u2019, which includes overweight, obesity and cardiovascular\u2010related diseases, causing a sort of cascade of chronic health conditions, which is becoming a norm in modern life. Hypercholesterolaemia is one of these. It represents an example of a pathology that can be linked to both a poor lifestyle and dietary habits. The nutraceutical approach to hypercholesterolaemia is described in the present review as a possible alternative to the conventional drug\u2010based therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. 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