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The biology, pharmacology and biochemistry of the receptors for angiotensins were extensively reviewed recently. In the review, the receptor nomenclature committee was not emphatic on designating MAS1 as the angiotensin 1\u20137 receptor on the basis of lack of classical G protein signalling and desensitization in response to angiotensin 1\u20137, as well as a lack of consensus on confirmatory ligand pharmacological analyses. A review of recent publications (2013\u20132016) on the rapidly progressing research on angiotensin 1\u20137 revealed that MAS1 and two additional receptors can function as \u2018angiotensin 1\u20137 receptors\u2019, and this deserves further consideration. In this review we have summarized the information on angiotensin 1\u20137 receptors and their crosstalk with classical angiotensin II receptors in the context of the functions of the renin angiotensin system. It was concluded that the receptors for angiotensin II and angiotensin 1\u20137 make up a sophisticated cross\u2010regulated signalling network that modulates the endogenous protective and pathogenic facets of the renin angiotensin system.<\/jats:p>","DOI":"10.1111\/bph.13742","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T08:12:46Z","timestamp":1487059966000},"page":"737-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Significance of angiotensin 1\u20137 coupling with MAS1 receptor and other GPCRs to the renin\u2010angiotensin system: IUPHAR Review 22"],"prefix":"10.1111","volume":"174","author":[{"given":"Sadashiva S","family":"Karnik","sequence":"first","affiliation":[{"name":"Department of Molecular Cardiology, Lerner Research Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuraijam 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