{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:04:45Z","timestamp":1790928285461,"version":"4.1.0"},"reference-count":238,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,26]],"date-time":"2017-03-26T00:00:00Z","timestamp":1490486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for potential therapeutic repurposing for non\u2010oncological indications. Considering (a) the preclinical efficacy data with PARP inhibitors in non\u2010oncological diseases and (b) the risk\u2013benefit ratio of treating patients with a compound that inhibits an enzyme that has physiological roles in the regulation of DNA repair, we have selected indications, where (a) the severity of the disease is high, (b) the available therapeutic options are limited, and (c) the duration of PARP inhibitor administration could be short, to provide first\u2010line options for therapeutic repurposing. These indications are as follows: acute ischaemic stroke; traumatic brain injury; septic shock; acute pancreatitis; and severe asthma and severe acute lung injury. In addition, chronic, devastating diseases, where alternative therapeutic options cannot halt disease development (e.g. Parkinson's disease, progressive multiple sclerosis or severe fibrotic diseases), should also be considered. We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Inventing New Therapies Without Reinventing the Wheel: The Power of Drug Repurposing. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.2\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.2\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13748","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T07:32:43Z","timestamp":1487403163000},"page":"192-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["Opportunities for the repurposing of PARP inhibitors for the therapy of non\u2010oncological diseases"],"prefix":"10.1111","volume":"175","author":[{"given":"Nathan A","family":"Berger","sequence":"first","affiliation":[{"name":"Center for Science, Health and Society Case Western Reserve University School of Medicine  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie C","family":"Besson","sequence":"additional","affiliation":[{"name":"EA4475 \u2013 Pharmacologie de la Circulation C\u00e9r\u00e9brale, Facult\u00e9 de Pharmacie de Paris Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Hamid","family":"Boulares","sequence":"additional","affiliation":[{"name":"The Stanley Scott Cancer Center, School of Medicine Louisiana State University Health Sciences Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"B\u00fcrkle","sequence":"additional","affiliation":[{"name":"Molecular Toxicology Group, Department of Biology University of Konstanz  Constance Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Chiarugi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Clinical Pharmacology and Oncology, Headache Center \u2013 University Hospital University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Safar Center for Resuscitation Research University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J","family":"Curtin","sequence":"additional","affiliation":[{"name":"Newcastle University, Northern Institute for Cancer Research, Medical School University of Newcastle Upon Tyne  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted M","family":"Dawson","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering and Department of Neurology and Department of Pharmacology and Molecular Sciences and Solomon H. 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