{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:30:32Z","timestamp":1790523032899,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91639204, 81400203, 81330004, 31371156, 81670209"],"award-info":[{"award-number":["91639204, 81400203, 81330004, 31371156, 81670209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670209"],"award-info":[{"award-number":["81670209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371156"],"award-info":[{"award-number":["31371156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330004"],"award-info":[{"award-number":["81330004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91639204"],"award-info":[{"award-number":["91639204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400203"],"award-info":[{"award-number":["81400203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S), independently of any specific transporters, has a number of biological effects on the cardiovascular system. However, until now, the detailed mechanism of H\n                      <jats:sub>2<\/jats:sub>\n                      S was not clear. Recently, a novel post\u2010translational modification induced by H\n                      <jats:sub>2<\/jats:sub>\n                      S, named S\u2010sulfhydration, has been proposed. S\u2010sulfhydration is the chemical modification of specific cysteine residues of target proteins by H\n                      <jats:sub>2<\/jats:sub>\n                      S. There are several methods for detecting S\u2010sulfhydration, such as the modified biotin switch assay, maleimide assay with fluorescent thiol modifying regents, tag\u2010switch method and mass spectrometry. H\n                      <jats:sub>2<\/jats:sub>\n                      S induces S\u2010sulfhydration on enzymes or receptors (such as p66Shc, phospholamban, protein tyrosine phosphatase 1B, mitogen\u2010activated extracellular signal\u2010regulated kinase 1 and ATP synthase subunit \u03b1), transcription factors (such as specific protein\u20101, kelch\u2010like ECH\u2010associating protein 1, NF\u2010\u03baB and interferon regulatory factor\u20101), and ion channels (such as voltage\u2010activated Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channels, transient receptor potential channels and ATP\u2010sensitive K\n                      <jats:sup>+<\/jats:sup>\n                      channels) in the cardiovascular system. Although significant progress has been achieved in delineating the role of protein S\u2010sulfhydration by H\n                      <jats:sub>2<\/jats:sub>\n                      S in the cardiovascular system, more proteins with detailed cysteine sites of S\u2010sulfhydration as well as physiological function need to be investigated in further studies. This review mainly summarizes the role and possible mechanism of S\u2010sulfhydration in the cardiovascular system. The S\u2010sulfhydrated proteins may be potential novel targets for therapeutic intervention and drug design in the cardiovascular system, which may accelerate the development and application of H\n                      <jats:sub>2<\/jats:sub>\n                      S\u2010related drugs in the future.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.13825","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T07:13:23Z","timestamp":1492845203000},"page":"1146-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Protein S\u2010sulfhydration by hydrogen sulfide in cardiovascular system"],"prefix":"10.1111","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-6543","authenticated-orcid":false,"given":"Guoliang","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Nantong University  Nantong China"},{"name":"Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease and Molecular Intervention Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease and Molecular Intervention Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Geriatrics First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-5747","authenticated-orcid":false,"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Cardiovascular Disease and Molecular Intervention Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.06.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13347"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13349"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13352"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13353"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13354"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005478"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.03.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00385"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805287200"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12517"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022967"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303450"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517995"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.12.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6596"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2015.02.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10067"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.048"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2807490"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.041"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321232111"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.07.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00281.2014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.08.026"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8941"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002329"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6186"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12585"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12451"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4234"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.03.005"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12246"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002208"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13583"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00088.2013"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12900"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats","volume":"29","author":"Meng G","year":"2015","journal-title":"J Biomed Res"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/691070"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004160"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.019"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.08.023"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.07.001"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240242"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00465.2016"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1018"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103503108"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.11.066"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3245"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb4001052"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.033"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.007"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.021"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.12.023"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12475"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12535"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.290re7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-278648"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.12.015"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.021"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8935"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002368"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw037"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4565"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004320"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6369"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2623"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC04818D"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6331"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0020"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6043038"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5604"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4645"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.007"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.15-293"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305876"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037073"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/323269"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/embr.201338213"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.13825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:07:46Z","timestamp":1694426866000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.13825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,24]]},"references-count":86,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/bph.13825"],"URL":"https:\/\/doi.org\/10.1111\/bph.13825","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,24]]},"assertion":[{"value":"2017-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}