{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:59Z","timestamp":1787013959377,"version":"build-2736575974"},"reference-count":90,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91439110"],"award-info":[{"award-number":["91439110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400311"],"award-info":[{"award-number":["81400311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Sulfur\u2010containing gaseous signal molecules including hydrogen sulphide and sulfur dioxide were previously recognized as toxic gases. However, extensive studies have revealed that they can be generated in the cardiovascular system\n                      <jats:italic>via<\/jats:italic>\n                      a sulfur\u2010containing amino acid metabolic pathway, and have an important role in cardiovascular physiology and pathophysiology. Ion channels are pore\u2010forming\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Membrane_protein\">membrane protein<\/jats:ext-link>\n                      s present in the membrane of all biological cells; their functions include the establishment of a\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Resting_membrane_potential\">resting membrane potential<\/jats:ext-link>\n                      and the control of\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Action_potential\">action potentials<\/jats:ext-link>\n                      and other electrical signals by conducting\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Ion\">ions<\/jats:ext-link>\n                      across the cell membrane. Evidence has now accumulated suggesting that the sulfur\u2010containing gaseous signal molecules are important regulators of ion channels and transporters. The aims of this review are (1) to discuss the recent experimental evidences in the cardiovascular system regarding the regulatory effects of sulfur\u2010containing gaseous signal molecules on a variety of ion channels, including ATP\u2010sensitive potassium, calcium\u2010activated potassium, voltage\u2010gated potassium, L\u2010 and T\u2010type calcium, transient receptor potential and chloride and sodium channels, and (2) to understand how the gaseous signal molecules affect ion channels and cardiovascular diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.13829","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T09:11:18Z","timestamp":1492765878000},"page":"1114-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Sulfur\u2010containing gaseous signal molecules, ion channels and cardiovascular diseases"],"prefix":"10.1111","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-6896","authenticated-orcid":false,"given":"Wen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Peking University First 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