{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:33Z","timestamp":1790790813097,"version":"4.1.0"},"reference-count":129,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/14\/71\/31063, PG\/14\/70\/31039 and FS\/15\/16\/31477"],"award-info":[{"award-number":["PG\/14\/71\/31063, PG\/14\/70\/31039 and FS\/15\/16\/31477"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/15\/16\/31477"],"award-info":[{"award-number":["FS\/15\/16\/31477"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/14\/70\/31039"],"award-info":[{"award-number":["PG\/14\/70\/31039"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/14\/71\/31063"],"award-info":[{"award-number":["PG\/14\/71\/31063"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>p21\u2010activated kinase 1 (Pak1) is a member of the highly conserved family of serine\/threonine protein kinases regulated by Ras\u2010related small G\u2010proteins, Cdc42\/Rac1. It has been previously demonstrated to be involved in cardiac protection. Based on recent studies, this review provides an overview of the role of Pak1 in cardiac diseases including disrupted Ca<jats:sup>2+<\/jats:sup> homoeostasis\u2010related cardiac arrhythmias, adrenergic stress\u2010 and pressure overload\u2010induced hypertrophy, and ischaemia\/reperfusion injury. These findings demonstrate the important role of Pak1 mediated through the phosphorylation and transcriptional modification of hypertrophy and\/or arrhythmia\u2010related genes. This review also discusses the anti\u2010arrhythmic and anti\u2010hypertrophic, protective function of Pak1 and the beneficial effects of fingolimod (an FDA\u2010approved sphingolipid drug), a Pak1 activator, and its ability to prevent arrhythmias and cardiac hypertrophy. These findings also highlight the therapeutic potential of Pak1 signalling in the treatment and prevention of cardiac diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13872","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T10:12:45Z","timestamp":1496398365000},"page":"1362-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The p21\u2010activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration"],"prefix":"10.1111","volume":"175","author":[{"given":"Yanwen","family":"Wang","sequence":"first","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology The University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Boyett","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoyee","family":"Tsui","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-0785","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-894X(95)00127-F"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13349"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13354"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-016-0267-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0861-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh2301.100003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00520.2005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309937200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704548"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/415198a"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161742"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1307"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.12.026"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.704197"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.12.4124-4135.2002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.126714"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000033988.13062.7C"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.02.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu123"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6350"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145659.80212.6A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00020-3"},{"key":"e_1_2_9_24_1","first-page":"8837","article-title":"Activation of p21\u2010activated kinase 1\u2010nuclear factor \u03baB signaling by Kaposi's sarcoma\u2010associated herpes virus G protein\u2010coupled receptor during cellular transformation","volume":"63","author":"Dadke D","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000340"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv234"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.08.011"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.823070"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.034868"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021423"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.10.009"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2010.01.001"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01003.2010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2752-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01003.2010"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn208"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi952940f"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.660"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405770200"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s004249900067","article-title":"Effects of sphingosine 1\u2010phosphate on pacemaker activity in rabbit sino\u2010atrial node cells","volume":"438","author":"Guo J","year":"1999","journal-title":"Pflugers Arch"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp137"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.125pe31"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.05.028"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00158-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113526"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01142.2005"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413374200"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.029"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01029.2001"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2015.05.001"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403960200"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00589.2011"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000111522.02730.56"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000266742.51389.a4"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2009.01.007"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01070.2009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1347-8"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2010.492779"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2014.08.007"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"11006","DOI":"10.1016\/S0021-9258(17)39139-1","article-title":"Regulation of calcium transport by protein phosphatase activity associated with cardiac sarcoplasmic reticulum","volume":"260","author":"Kranias EG","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_9_62_1","volume-title":"Adv Cancer Res","author":"Kumar R","year":"2016"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.12.014"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.5.H1625"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.11.015"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2001.tb00068.x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00043-X"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.03.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.12.012"},{"key":"e_1_2_9_70_1","first-page":"1769","article-title":"Cardiomyocyte specific deletion of PP2A causes cardiac hypertrophy","volume":"8","author":"Li L","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.10.005"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa5876"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.01.013"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.048785"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.188292"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000123"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.08.002"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.188649"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb15871.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37694"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.10.016"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03846-2"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(03)00087-1"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80371-6"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062453699"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181e1d263"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035875"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00612.2011"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01656.x"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.149047"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00253.2007"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00012.2008"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/298576a0"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00428-2"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.011"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314142200"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000035854.11082.01"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.017"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12113"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5410.2083"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807414200"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.105"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1492806"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009426107"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.159517"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1067\/mnc.2002.127626"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.10.015"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8497"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.065"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.09.016"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06068"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.9.3726-3736.2005"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0282OC"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.894648"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101974"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001198"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00270"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200616200"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307261200"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806487200"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.11.001"},{"key":"e_1_2_9_123_1","first-page":"765","article-title":"Cellular and molecular mechanisms of endothelial ischemia\/reperfusion injury: perspectives and implications for postischemic myocardial protection","volume":"8","author":"Yang Q","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.07.024"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500097200"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1911"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-015-9341-z"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1504-2"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12309"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.08.035"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.13872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T14:07:41Z","timestamp":1694441261000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.13872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":129,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/bph.13872"],"URL":"https:\/\/doi.org\/10.1111\/bph.13872","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]},"assertion":[{"value":"2017-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}