{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:53:17Z","timestamp":1789516397744,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473392"],"award-info":[{"award-number":["81473392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Morin is a natural occurring flavonoid in many dietary plants and has a wide range of beneficial effects on metabolism; however, the mechanism underlying its action remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>A reporter assay and the time\u2010resolved FRET assay were used to identify morin as a dual antagonist of liver X receptor (LXR)\u2010\u03b1 and \u2010\u03b2. Morin (100\u00a0mg<jats:sup>.<\/jats:sup>100\u00a0g<jats:sup>\u20101<\/jats:sup> diet) was administered to high\u2010fat diet\u2010induced obese or <jats:italic>LXR\u03b2<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. The pharmacological effects and mechanism of action of morin were evaluated by Western blot and RT\u2010PCR analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>From the <jats:italic>in vitro<\/jats:italic> assays, morin was shown to be a dual antagonist of LXR\u03b1 and LXR\u03b2. <jats:italic>In vivo,<\/jats:italic> morin blunted the development of liver hepatic steatosis, reduced body weight gains, lowered triglyceride levels and improved glucose and insulin tolerance in mice fed a high\u2010fat diet. Mechanistically, morin inhibited 3T3\u2010L1 adipocyte differentiation and lipid formation in human hepatic HepG2 cells and suppressed the mRNA expression of genes downstream of LXR. Consistently, the effects of morin on metabolic disorders were attenuated in <jats:italic>LXR\u03b2<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Our data reveal that morin is a dual antagonist of LXR\u03b1 and LXR\u03b2 and suggest that morin may alleviate hepatic steatosis and other associated metabolic disorders via the suppression of LXR signalling and, therefore, shows promise as a novel therapy or nutraceutical for nonalcoholic fatty liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13933","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T03:42:37Z","timestamp":1498275757000},"page":"3032-3044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Morin, a novel liver X receptor \u03b1\/\u03b2 dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty 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