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Oxidative mechanisms play an important role in the pathophysiology and progression of this disease. The administration of pterostilbene (PTS), a phytophenol with antioxidant potential, may represent a therapeutic option. In the present study, we evaluated the effect of PTS complexed with hydroxypropyl\u2010\u03b2\u2010cyclodextrin (HP\u03b2CD) on hypertrophy, contractile function and oxidative parameters in the RV of rats with pulmonary hypertension, induced by the administration of monocrotaline (MCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>The rats received daily doses of the PTS\u00a0:\u00a0HP\u03b2CD complex at 25, 50 or 100\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, p.o., for 14\u00a0days. The diastolic function, E\/A ratio, and systolic function, shortening fraction, fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE) of the RV were determined by echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The PTS\u00a0:\u00a0HP\u03b2CD complex reduced the production of NADPH oxidase\u2010dependent superoxide anions and oxidative stress in the RV of MCT\u2010treated rats in a dose\u2010dependent manner. At higher doses it prevented the reduction in FAC and TAPSE in MCT\u2010treated animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>The PTS\u00a0:\u00a0HP\u03b2CD complex prevented the maladaptative remodelling and protected systolic function in the RV of rats with pulmonary hypertension. These cardioprotective mechanisms may be related, in part, to the antioxidant potential of PTS, favoured by the increased p.o. bioavailability promoted by the presence of HP\u03b2CD in the complex.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.13948","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T09:51:00Z","timestamp":1499939460000},"page":"3302-3314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in <i>cor pulmonale<\/i> model"],"prefix":"10.1111","volume":"174","author":[{"given":"Denise","family":"dos Santos Lacerda","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancia Biol\u00f3gicas: Farmacologia e Terap\u00eautica Universidade Federal do Rio Grande do Sul \u2013 UFRGS  Porto Alegre 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