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We review the current literature and highlight the differences between the \u03b2\u2010catenin\u2010dependent and \u2010independent branches of Wnt signalling. Special attention is paid to the role of the non\u2010canonical Wnt\/planar cell polarity (PCP) pathway, mediated by the Wnt\u20105\u2013receptor tyrosine kinase\u2010like orphan receptor (ROR1)\u2013Dishevelled signalling axis in CLL. This is mainly because the Wnt\/PCP co\u2010receptor ROR1 was found to be overexpressed in CLL and the Wnt\/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro\u2010environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B\u2010cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v174.24\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v174.24\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.13949","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T06:11:33Z","timestamp":1499926293000},"page":"4701-4715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Wnt signalling pathways in chronic lymphocytic leukaemia and B\u2010cell lymphomas"],"prefix":"10.1111","volume":"174","author":[{"given":"Pavl\u00edna","family":"Janovsk\u00e1","sequence":"first","affiliation":[{"name":"Institute of Experimental Biology, Faculty of Science Masaryk University  Brno Czech 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