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Finally, bias at the level of the receptor, by the expression of genetic receptor variants, will be discussed to show how a modified receptor function can have an effect on the risk for common diseases like type 2 diabetes in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.16\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.16\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.13950","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T21:08:38Z","timestamp":1499980118000},"page":"3263-3280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":246,"title":["Melatonin receptors: molecular pharmacology and signalling in the context of system bias"],"prefix":"10.1111","volume":"175","author":[{"given":"Erika","family":"Cecon","sequence":"first","affiliation":[{"name":"Institut Cochin Inserm, U1016  Paris France"},{"name":"CNRS UMR 8104  Paris France"},{"name":"Univ. 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