{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:19:05Z","timestamp":1789057145808,"version":"build-2803163510"},"reference-count":166,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81220108004"],"award-info":[{"award-number":["81220108004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81225002"],"award-info":[{"award-number":["81225002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670436"],"award-info":[{"award-number":["81670436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91539203"],"award-info":[{"award-number":["91539203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Homocysteine is a sulphur\u2010containing non\u2010proteinogenic amino acid. Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a result of an imbalance of its metabolism, is an independent risk factor for various vascular diseases, such as atherosclerosis, hypertension, vascular calcification and aneurysm. Treatments aimed at lowering plasma homocysteine\n                      <jats:italic>via<\/jats:italic>\n                      dietary supplementation with folic acids and vitamin B are more effective in preventing vascular disease where the population has a normally low folate consumption than in areas with higher dietary folate. To date, the mechanisms of HHcy\u2010induced vascular injury are not fully understood. HHcy increases oxidative stress and its downstream signalling pathways, resulting in vascular inflammation. HHcy also causes vascular injury\n                      <jats:italic>via<\/jats:italic>\n                      endoplasmic reticulum stress. Moreover, HHcy up\u2010regulates pathogenic genes and down\u2010regulates protective genes\n                      <jats:italic>via<\/jats:italic>\n                      DNA demethylation and methylation respectively. Homocysteinylation of proteins induced by homocysteine also contributes to vascular injury by modulating intracellular redox state and altering protein function. Furthermore, HHcy\u2010induced vascular injury leads to neuronal damage and disease. Also, an HHcy\u2010activated sympathetic system and HHcy\u2010injured adipose tissue also cause vascular injury, thus demonstrating the interactions between the organs injured by HHcy. Here, we have summarized the recent developments in the mechanisms of HHcy\u2010induced vascular injury, which are further considered as potential therapeutic targets in this condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.8\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.13988","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T02:05:16Z","timestamp":1503540316000},"page":"1173-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets"],"prefix":"10.1111","volume":"175","author":[{"given":"Yi","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Peking University, Health Science Center  Beijing China"},{"name":"Key Laboratory of Molecular Cardiovascular Science Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Peking University, Health Science Center  Beijing China"},{"name":"Key Laboratory of Molecular Cardiovascular Science Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-6810","authenticated-orcid":false,"given":"Wei","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Peking University, Health Science Center  Beijing China"},{"name":"Key Laboratory of Molecular Cardiovascular Science Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13354"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13348"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13350"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13349"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13355"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13347"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13352"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.11.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000108264.67601.2C"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.11.032"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000251536.49581.8a"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009136"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/18746098112059990007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-005-0404-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297912020022"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.116038"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.000588"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297911040109"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147825.97879.E7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.07.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0106-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0679-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.171082"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.10.015"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.02.021"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.5.433"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7272694"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001177"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.02.003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.08.020"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.10.030"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.03.007"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X0501000105"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600613"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1385\/CT:5:1:009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.7.795"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-017-0130-8"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.3.526"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-016-0245-x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp182"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20069"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01809.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.2.275"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.602532"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606235200"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/00029330-200811020-00011","article-title":"Diet\u2010induced hyperhomocysteinemia exacerbates vascular reverse remodeling of balloon\u2010injured arteries in rat","volume":"121","author":"Guo YH","year":"2008","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2335-0"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2249"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2016.11.003"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1158"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1231695"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60872-6"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212897200"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.022"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.15.2277"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00085-3"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200267200"},{"issue":"9","key":"e_1_2_10_62_1","first-page":"155","article-title":"The pathophysiological hypothesis of homocysteine thiolactone\u2010mediated vascular disease","volume":"59","author":"Jakubowski H","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.45"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-096701"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01369.x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3533"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i12.1699"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2011.00287.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4975"},{"key":"e_1_2_10_70_1","first-page":"282","article-title":"Homocysteine\u2010induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells","volume":"68","author":"Jia SJ","year":"2013","journal-title":"Pharmazie"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00304.2009"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5315"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2007.00327.x"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2007.00291.x"},{"key":"e_1_2_10_75_1","first-page":"191","article-title":"Homocysteine induces endothelial dysfunction via inhibition of arginine transport","volume":"58","author":"Jin L","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36362"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24722"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13234"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0270-7"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45067-9"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-016-2375-0"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314522136"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr250"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.154781"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437098"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9958-5"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.784965"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/679635"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmp033"},{"key":"e_1_2_10_90_1","first-page":"6670","article-title":"Homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) jointly elevate the risk of folate deficiency","volume":"7","author":"Li WX","year":"2015","journal-title":"Forum Nutr"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0617"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gms119"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr009"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17966"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12017"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.270520"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360753"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs130"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307674"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs330"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306088"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000023899.93940.7C"},{"key":"e_1_2_10_104_1","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully KS","year":"1969","journal-title":"Am J Pathol"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13148-011-0022-x"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.03622"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02976.x"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.15171\/jnp.2016.18"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081386"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.08.008"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.093976"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13705"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.959.415k20_959_967"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.06.021"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-006-9040-z"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x05vm626oa"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.015"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.3.636"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1655"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529503"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022661"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03117-9"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011613"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.11.002"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101733"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9151-1"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183802"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.1999.1.3-365"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.10.017"},{"key":"e_1_2_10_131_1","first-page":"129","article-title":"Homocysteine altered ROS generation and NO accumulation in endothelial cells","volume":"46","author":"Tsen CM","year":"2003","journal-title":"Chin J Physiol"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2005"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084503.91330.49"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07391-2"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1771"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3520817"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.25380"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.07.021"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613519849"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.002"},{"key":"e_1_2_10_141_1","first-page":"22","article-title":"Homocysteine\u2010induced nitric oxide production in vascular smooth\u2010muscle cells by NF\u2010kappa B\u2010dependent transcriptional activation of Nos2","volume":"110","author":"Welch GN","year":"1998","journal-title":"Proc Assoc Am Physicians"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108350"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.71"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12101"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.11.010"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9202"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.022384"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12510"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151119487"},{"key":"e_1_2_10_150_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1089\/dna.2007.0584","article-title":"Homocysteine\u2010mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs","volume":"26","author":"Yideng J","year":"2007","journal-title":"DNA Cell Biol"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2007.0619"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2007.0658"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00687.x"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-015-9464-5"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000087642.01082.E4"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.010"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.269472"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866889"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303899"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.259325"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4558"},{"key":"e_1_2_10_162_1","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1097\/00029330-200712010-00013","article-title":"Dysfunction of endothelial NO system originated from homocysteine\u2010induced aberrant methylation pattern in promoter region of DDAH2 gene","volume":"120","author":"Zhang JG","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00376-5"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00541-7"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.4.F671"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/724876"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12234"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.13988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.13988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:08:23Z","timestamp":1694426903000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.13988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":166,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/bph.13988"],"URL":"https:\/\/doi.org\/10.1111\/bph.13988","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]},"assertion":[{"value":"2017-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}