{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:08:56Z","timestamp":1767676136876,"version":"3.41.0"},"reference-count":62,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA07315"],"award-info":[{"award-number":["DA07315"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The \u03ba receptor antagonists have potential for treating neuropsychiatric disorders. We have investigated the<jats:italic>in vivo<\/jats:italic>pharmacology of a novel buprenorphine analogue, BU10119, for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>To determine the opioid pharmacology of BU10119 (0.3\u20133\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, i.p.)<jats:italic>in vivo<\/jats:italic>, the warm\u2010water tail\u2010withdrawal assay was applied in adult male CD1 mice. A range of behavioural paradigms was used to investigate the locomotor effects, rewarding properties and antidepressant or anxiolytic potential of BU10119. Additional groups of mice were exposed to a single (1\u00a0\u00d7\u00a02\u00a0h) or repeated restraint stress (3\u00d7 daily 2\u00a0h) to determine the ability of BU10119 to block stress\u2010induced analgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>BU10119 alone was without any antinociceptive activity. BU10119 (1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) was able to block U50,488, buprenorphine and morphine\u2010induced antinociception. The \u03ba antagonist effects of BU10119 in the tail\u2010withdrawal assay reversed between 24 and 48\u00a0h. BU10119 was without significant locomotor or rewarding effects. BU10119 (1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) significantly reduced the latency to feed in the novelty\u2010induced hypophagia task and reduced immobility time in the forced swim test, compared to saline\u2010treated animals. There were no significant effects of BU10119 in either the elevated plus maze or the light\u2013dark box. Both acute and repeated restraint stress\u2010induced analgesia were blocked by pretreatment with BU10119 (1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>). Parallel stress\u2010induced increases in plasma corticosterone were not affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>BU10119 is a mixed \u03ba\/\u03bc receptor antagonist with relatively short\u2010duration \u03ba antagonist activity. Based on these preclinical data, BU10119 has therapeutic potential for the treatment of depression and other stress\u2010induced conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Emerging Areas of Opioid Pharmacology. To view the other articles in this section visit<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.14\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v175.14\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14060","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T02:56:36Z","timestamp":1506912996000},"page":"2869-2880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antidepressant\u2010like effects of BU10119, a novel buprenorphine analogue with mixed \u03ba\/\u03bc receptor antagonist properties, in mice"],"prefix":"10.1111","volume":"175","author":[{"given":"Abdulrahman","family":"Almatroudi","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Ostovar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M","family":"Husbands","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-8479","authenticated-orcid":false,"given":"Sarah J","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1073\/pnas.0910180106"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1111\/bph.13348"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1007\/s00213-012-2930-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1177\/0269881115586937"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.3109\/10253890903362645"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0022-3565(24)39155-4","article-title":"Methocinnamox is a potent, long\u2010lasting, and selective antagonist of morphine\u2010mediated antinociception in the mouse: comparison with clocinnamox, beta\u2010funaltrexamine, and beta\u2010chlornaltrexamine","volume":"294","author":"Broadbear JH","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/j.pneurobio.2009.04.003"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1021\/jm301783x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1177\/0269881112464828"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1021\/cn4001507"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.drugalcdep.2014.06.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1002\/(SICI)1098-2396(199703)25:3<309::AID-SYN11>3.0.CO;2-R"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1038\/sj.npp.1300934"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1111\/adb.12020"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1016\/S0165-6147(02)02017-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1021\/acs.jmedchem.5b00130"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1111\/bph.12856"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1016\/j.neubiorev.2005.03.017"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1038\/npp.2014.330"},{"key":"e_1_2_10_21_1","first-page":"30","article-title":"Nor\u2010binaltorphimine: a potent and selective kappa\u2010opioid receptor antagonist with long\u2010lasting activity in vivo","volume":"316","author":"Endoh T","year":"1992","journal-title":"Arch Int Pharmacodyn Ther"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1016\/S0031-9384(97)00520-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1177\/0269881106060835"},{"unstructured":"HillhouseTM HallahanJE JutkiewiczEM HusbandsSM TraynorJR(2016).A buprenorphine analog attenuates drug\u2010primed and stress\u2010induced cocaine reinstatement. 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