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The main, recognized molecular targets of H<jats:sub>2<\/jats:sub>S, that is, potassium channels and PDEs, have been evaluated in SKM physiology in order to hypothesize a role for H<jats:sub>2<\/jats:sub>S signalling. SKM dysfunctions, including muscular dystrophy and malignant hyperthermia, have also been evaluated as conditions in which the H<jats:sub>2<\/jats:sub>S and transsulfuration pathways have been suggested to be involved. The intrinsic complexity of the molecular mechanisms involved in excitation\u2010contraction (E\u2010C) coupling together with the scarcity of preclinical models of SKM\u2010related disorders have hampered any advances in the knowledge of SKM function. Here, we have addressed the role of the H<jats:sub>2<\/jats:sub>S pathway in E\u2010C coupling and the relative importance of cystathionine \u03b2\u2010synthase, cistathionine \u03b3\u2010lyase and 3\u2010mercaptopyruvate sulfurtransferase in SKM diseases.<\/jats:p>","DOI":"10.1111\/bph.14358","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T09:29:10Z","timestamp":1526462950000},"page":"3090-3099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hydrogen sulfide pathway and skeletal muscle: an introductory review"],"prefix":"10.1111","volume":"175","author":[{"given":"Valentina","family":"Vellecco","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Medicine University of Naples \u2018Federico II\u2019 Naples 80131 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