{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:31Z","timestamp":1787312671155,"version":"build-2736575974"},"reference-count":237,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["5182010"],"award-info":[{"award-number":["5182010"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31521062"],"award-info":[{"award-number":["31521062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671177"],"award-info":[{"award-number":["31671177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170100"],"award-info":[{"award-number":["81170100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370234"],"award-info":[{"award-number":["81370234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601431"],"award-info":[{"award-number":["81601431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2013CB531200"],"award-info":[{"award-number":["2013CB531200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades, most work on cell death has focused on apoptosis, which is generally considered as the only form of regulated cell death, whereas necrosis has been regarded to be an unregulated process. Recent findings reveal that necrosis also occurs in a regulated manner and that it is closely related to the physiology and pathophysiology of many organs, including the heart. The recognition of necrosis as a regulated process mandates a re\u2010examination of cell death in the heart together with the mechanisms and therapy of cardiac diseases. In this study, we summarize the regulatory mechanisms of the programmed necrosis of cardiomyocytes, that is, the intrinsic (mitochondrial) and extrinsic (death receptor) pathways. Furthermore, the role of this programmed necrosis in various heart diseases is also delineated. Finally, we describe the currently known pharmacological inhibitors of several of the key regulatory molecules of regulated cell necrosis and the opportunities for their therapeutic use in cardiac disease. We intend to systemically summarize the recent progresses in the regulation and pathological significance of programmed cardiomyocyte necrosis along with its potential therapeutic applications to cardiac diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.22\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.22\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14363","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T03:50:52Z","timestamp":1526615452000},"page":"4319-4339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-8675","authenticated-orcid":false,"given":"Junxia","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Institute of Molecular Medicine Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Institute of Molecular Medicine Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Institute of Molecular Medicine Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Institute of Molecular Medicine Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607769113"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02831.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.09.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313329200"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13883"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13880"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198912000-00006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0022-3565(24)37893-0","article-title":"KN\u201093, an inhibitor of multifunctional Ca++\/calmodulin\u2010dependent protein kinase, decreases early after depolarizations in rabbit heart","volume":"287","author":"Anderson ME","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.12.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00452.2017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813013106"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03434"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1575"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1249614"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2015.9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0124-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1994.1115"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020944"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04544.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.899732"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000163398.79679.66"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.11.013"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305633200"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.06.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453217"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.435545"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01104.2010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.12.013"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00759.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.037"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.04.002"},{"key":"e_1_2_9_37_1","first-page":"212","article-title":"Necrostatin\u20101 is a novel protector of myocardial infarction","volume":"114","author":"Chua BH","year":"2006","journal-title":"Circulation"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202191200"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2840381"},{"key":"e_1_2_9_40_1","first-page":"423","article-title":"Myocarditis REPLY","volume":"361","author":"Cooper L","year":"2009","journal-title":"New Engl J Med"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.83"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.133"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00239.2009"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.08.010"},{"key":"e_1_2_9_46_1","first-page":"15960","article-title":"Activation of TRAF2\u2010NF\u2010\u03baB signaling suppresses mitochondrial perturbations in doxorubicin cardiotoxicity","volume":"130","author":"Dhingra R","year":"2014","journal-title":"Circulation"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-013-2124-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00050-3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn243"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.03.026"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0321"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43171"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.130"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.159"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.12.007"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.06.017"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.06.011"},{"key":"e_1_2_9_59_1","first-page":"179","article-title":"Safety, tolerability and pharmacokinetics of SMP\u2010114 (a novel candidate DMARD) in healthy volunteers","volume":"62","author":"Gaskin C","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217823110"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9531-1"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00165.2005"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01378.2006"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.100788"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00498-X"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000231397.64362.70"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1993.1162"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.9.856"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900226106"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026240"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680153"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12899"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.223"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.06.014"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml400382p"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.025"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(98)00156-9"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.021"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.10.012"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.937"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.121"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408987111"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.044"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/82732"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80984-8"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20010172"},{"key":"e_1_2_9_88_1","doi-asserted-by":"crossref","first-page":"18536","DOI":"10.1161\/circ.132.suppl_3.18536","article-title":"Nanoparticle\u2010mediated simultaneous targeting to mitochondria and inflammatory monocytes confers additive cardioprotection against myocardial ischemia\u2013reperfusion injury","volume":"132","author":"Ikeda G","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2040"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11444"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt120"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.003"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00772"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305421"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248411407636"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248410362074"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.982777"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.5.1353"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-012-0084-9"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.03.008"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2008.41.8.555"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400526"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303312"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04925.x"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.224915"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-013-1716-3"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12391"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00199"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.225730"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00209.2008"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00777.2002"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.6.1066"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.241"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2782"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.430"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3006"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02241.x"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-007-6067-6"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.19.2514"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38022"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305538110"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00423"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.357"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-016-0039-8"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_2_9_126_1","first-page":"UNSP 15027298","article-title":"Protective effect of necrostatin\u20101 on myocardial tissue in rats with acute myocardial infarction","volume":"15","author":"Liu YR","year":"2016","journal-title":"Genet Mol Res"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu146"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800168105"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2549638"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.021"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02664"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312783110"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2184"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.1999.00102.x"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3170"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.052"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00521-X"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1736"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr302"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq206"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2007"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.052"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03317"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31060"},{"key":"e_1_2_9_145_1","first-page":"1989","article-title":"Effects of KN\u201062, an inhibitor of Ca2+\/calmodulin\u2010dependent protein kinase II (CaM kinase), on contractile function and protein phosphorylation in isolated\u2010perfused rabbit heart","volume":"10","author":"Narayanan N","year":"1996","journal-title":"FASEB J"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0637-y"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.46"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001639"},{"key":"e_1_2_9_149_1","doi-asserted-by":"crossref","unstructured":"NunesT BernardazziC(2014).Cell death and inflammatory bowel diseases: apoptosis necrosis and autophagy in the intestinal epithelium. Biomed Res Int 2014:218493.","DOI":"10.1155\/2014\/218493"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200116020-00001"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0270-8"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.02.029"},{"key":"e_1_2_9_153_1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0022-3565(25)22541-1","article-title":"KN\u201062, a specific Ca2+ calmodulin\u2010dependent protein\u2010kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes","volume":"270","author":"Okazaki K","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1180"},{"key":"e_1_2_9_155_1","first-page":"S646","article-title":"Effect of hypercholesterolemia on myocardial necrosis and apoptosis in response to ischemia reperfusion injury","volume":"118","author":"Osipov RM","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2012.00845.x"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14191"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7958"},{"key":"e_1_2_9_159_1","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1016\/S0021-9258(18)68626-0","article-title":"Calcium calmodulin\u2010dependent protein kinase II characterization of distinct calmodulin binding and inhibitory domains","volume":"263","author":"Payne ME","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00021"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8326749"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-010-9297-4"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071142"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3423"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.108"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041611398"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01007.x"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.732735"},{"key":"e_1_2_9_169_1","first-page":"455","article-title":"Necrostatin\u20101 stable variant suppress necroptosis in ischemic\u2013reperfusion hearts","volume":"33","author":"Qin D","year":"2017","journal-title":"J Clin Cardiol"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.5.684"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.531"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0119"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182456d46"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000266683.64081.02"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300639"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0212-0"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt091"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.166"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-010-6219-y"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.02.009"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-007-6035-1"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)92031-E"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.031"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28574"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000166925.45995.ed"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1174"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01108"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933105"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933393"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt142"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.176"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.348"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706802105"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.01.011"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118747"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.6.2215-2225.2006"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3726com"},{"key":"e_1_2_9_198_1","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1016\/S0021-9258(19)39565-1","article-title":"KN\u201062, 1\u2010[N,O\u2010bis (5\u2010isoquinolinesulfonyl)\u2010N\u2010methyl\u2010l\u2010tyrosyl]\u20104\u2010phenylpiperazine, a specific inhibitor of Ca2+\/calmodulin\u2010dependent protein kinase\u2010II","volume":"265","author":"Tokumitsu H","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800051200"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.03.006"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2970"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1477"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.12.003"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.3.375"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304678"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199605000-00003"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.036"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.030"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-013-1172-1"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.305781"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad6872"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.4065"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163111"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201608109"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1714"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.62"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027583.73268.E7"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806422106"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.01.016"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00432-9"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC00667E"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00353.2006"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.02.010"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0459-0"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072221"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.249532"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104257200"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"},{"key":"e_1_2_9_231_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12349"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4017"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-017-9441-z"},{"key":"e_1_2_9_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.316"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b04060"},{"key":"e_1_2_9_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3188-5"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27523"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000160521.91363.88"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.14363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.14363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.14363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.14363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T12:24:17Z","timestamp":1751631857000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.14363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":237,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/bph.14363"],"URL":"https:\/\/doi.org\/10.1111\/bph.14363","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]},"assertion":[{"value":"2018-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}