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The innate immune system, <jats:italic>via<\/jats:italic> toll\u2010like receptors (TLRs), identifies distinct signatures of invading microbes and damage\u2010associated molecular patterns and triggers a chain of downstream signalling cascades, leading to secretion of pro\u2010inflammatory cytokines and shaping the adaptive immune response. Over the past decade, a dysfunctional TLR\u2010mediated response, particularly <jats:italic>via<\/jats:italic> TLR4, has been suggested to support a chronic inflammatory state in hypertension, inducing deleterious local and systemic effects in host cells and tissues and contributing to disease progression. While the underlying mechanisms triggering TLR4 need further research, evidence suggests that sustained elevations in BP disrupt homeostasis, releasing endogenous TLR4 ligands in hypertension. In this review, we discuss the emerging role of TLR4 in the pathogenesis of hypertension and whether targeting this receptor and its signalling pathways could offer a therapeutic strategy for management of this multifaceted disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.12\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.12\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14438","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T08:27:55Z","timestamp":1530952075000},"page":"1864-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Targeting toll\u2010like receptor 4 signalling pathways: can therapeutics pay the toll for hypertension?"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-7617","authenticated-orcid":false,"given":"Kenia Pedrosa","family":"Nunes","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Florida Institute of Technology  Melbourne FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Almeida","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Florida Institute of Technology  Melbourne FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Elisabeth","family":"Mowry","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, and Pharmacology Auburn University  Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicia Campana","family":"Biancardi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, and Pharmacology Auburn University  Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.03.015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-9-48"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13876"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0201OC"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000129788.26346.18"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.09.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5259"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.434142"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.225"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9368-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.03.017"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00247.2015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110523"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.12.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.01.010"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2015.00020"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.09.011"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb03073.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.01.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.18740","article-title":"Swine IRF3\/IRF7 attenuates inflammatory responses through TLR4 signaling pathway","volume":"8","author":"Chen P\u2010G","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605545103"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu067"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0242-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104020"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","unstructured":"DoddapattarP GandhiC PrakashP DhaneshaN GrumbachIM DaileyMEet al. 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