{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:35Z","timestamp":1792000535251,"version":"4.4.0"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The transsulfuration pathway is a metabolic pathway where transfer of sulfur from homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur metabolites, which include cysteine, GSH and the gaseous signalling molecule hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S). Precise control of this pathway is critical for maintenance of optimal cellular function and, therefore, the key enzymes of the pathway, cystathionine \u03b2\u2010synthase and cystathionine \u03b3\u2010lyase, are regulated at multiple levels. Disruption of the transsulfuration pathway contributes to the pathology of several conditions such as vascular dysfunction, Huntington's disease and during ageing. Treatment with donors of hydrogen sulfide and\/or stimulation of this pathway have proved beneficial in several of these disorders. In this review, we focus on the regulation of the transsulfuration pathway pertaining to cysteine and H\n                      <jats:sub>2<\/jats:sub>\n                      S, which could be targeted to develop novel therapeutics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.4\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.4\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14446","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T06:05:01Z","timestamp":1531548301000},"page":"583-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":403,"title":["Regulators of the transsulfuration pathway"],"prefix":"10.1111","volume":"176","author":[{"given":"Juan I","family":"Sbodio","sequence":"first","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience The Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon H","family":"Snyder","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience The Johns Hopkins University School of Medicine  Baltimore MD USA"},{"name":"Department of Pharmacology and Molecular Sciences The Johns Hopkins University School of Medicine  Baltimore MD USA"},{"name":"Department of Psychiatry The Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":false,"given":"Bindu D","family":"Paul","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience The Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260427"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004032"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13880"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13882"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13879"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12171"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.02.021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.08.037"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400481200"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31491"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.09.014"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500968"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3724fje"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414545111"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3009693"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.06.017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115634109"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.01.017"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2017.0149"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's disease collaborative research group","volume":"72","author":"Group","year":"1993","journal-title":"Cell"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027598"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1268"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00105-9"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01949.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.048"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.003"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4944"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.147439"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1700-8"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102008108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3781"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C116.742213"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10847"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.01.004"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0723"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21273"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002329"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2017.05.011"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5865-09.2010"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5923"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105290"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.038"},{"key":"e_1_2_11_52_1","first-page":"OL1010","article-title":"Oxidative stress as a signal to up\u2010regulate \u03b3\u2010cystathionase in the fetal\u2010to\u2010neonatal transition in rats","volume":"53","author":"Martin JA","year":"2007","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010Grand)"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1444"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00032-8"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0864-8"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox6030062"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.04.004"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.15.3910"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-216507"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119658109"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi001088w"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199507060-00005"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240242"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5891"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.02.007"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13136"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.950538"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.007"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5917"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.11.019"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3698"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/768607"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509531103"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141082"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2097"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2406-8"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.843979"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608264113"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717877115"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2017.251"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.021"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/b604182p"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010868"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171042"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12675"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-9006-9"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805459200"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00282.2016"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12369"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.04.011"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(03)00008-1"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2623"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.253344"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602799200"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1585"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.154"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.131"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.266643"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4645"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2187-4"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.029"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.14446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.14446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:26:26Z","timestamp":1694427986000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.14446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":105,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/bph.14446"],"URL":"https:\/\/doi.org\/10.1111\/bph.14446","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"2018-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}