{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:14:47Z","timestamp":1787508887771,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Stress is known to reduce food intake. Many aspects of the stress response and feeding are regulated by the endocannabinoid system, but the roles of anandamide (AEA) and 2\u2010arachidonoyl glycerol (2\u2010AG) in stress\u2010induced anorexia are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Effects of acute restraint stress on endocannabinoids were investigated in male Sprague\u2013Dawley rats. Systemic and central pharmacological inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) was used to assess the effects of elevated AEA and 2\u2010AG on homeostatic feeding and on food consumption after stress. Animals were pretreated with the FAAH inhibitor, PF\u201004457845, or the MAGL inhibitor, MJN110, before 2\u00a0h acute restraint stress or 2\u00a0h homecage period without food.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Restraint stress decreased hypothalamic and circulating AEA, with no effect in the gastrointestinal tract, while 2\u2010AG content in the jejunum (but not duodenum) was reduced. PF\u201004457845 (30\u00a0\u03bcg), given i.c.v., attenuated stress\u2010induced anorexia\n                      <jats:italic>via<\/jats:italic>\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                      receptors, but reduced homeostatic feeding in unstressed animals through an unknown mechanism. On the other hand, systemic administration of MJN110 (10\u00a0mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) reduced feeding, regardless of stress or feeding status and inhibited basal intestinal transit in unstressed rats. The ability of MAGL inhibition to reduce feeding in combination with stress was independent of CB\n                      <jats:sub>1<\/jats:sub>\n                      receptor signalling in the gut as the peripherally restricted CB\n                      <jats:sub>1<\/jats:sub>\n                      receptor antagonist, AM6545 did not block this effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Our data reveal diverse roles for 2\u2010AG and AEA in homeostatic feeding and changes in energy intake following stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on 8\n                      <jats:sup>th<\/jats:sup>\n                      European Workshop on Cannabinoid Research. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.10\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.10\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14453","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T21:19:20Z","timestamp":1532639960000},"page":"1524-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Endocannabinoid regulation of homeostatic feeding and stress\u2010induced alterations in food intake in male rats"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7544-4613","authenticated-orcid":false,"given":"Martin A","family":"Sticht","sequence":"first","affiliation":[{"name":"Hotchkiss Brain 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