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Cysteine is taken up by mammals\n                      <jats:italic>via<\/jats:italic>\n                      their diet and can also be derived from methionine\n                      <jats:italic>via<\/jats:italic>\n                      the transsulfuration pathway. The cellular concentration of cysteine is kept within a narrow range by controlling its synthesis and degradation. There are two pathways for the catabolism of cysteine leading to sulfate, taurine and thiosulfate as terminal products. The oxidative pathway produces taurine and sulfate, while the H\n                      <jats:sub>2<\/jats:sub>\n                      S pathway involves different enzymatic reactions leading to the formation and clearance of H\n                      <jats:sub>2<\/jats:sub>\n                      S, an important signalling molecule in mammals, resulting in thiosulfate and sulfate. Sulfite is a common intermediate in both catabolic pathways. Sulfite is considered as cytotoxic and produces neurotoxic S\u2010sulfonates. As a result, a deficiency in the terminal steps of cysteine or H\n                      <jats:sub>2<\/jats:sub>\n                      S catabolism leads to severe forms of encephalopathy with the accumulation of sulfite and H\n                      <jats:sub>2<\/jats:sub>\n                      S in the body. This review links the homeostatic regulation of both cysteine catabolic pathways to sulfite and H\n                      <jats:sub>2<\/jats:sub>\n                      S.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.4\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v176.4\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14464","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T06:15:25Z","timestamp":1533708925000},"page":"554-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism"],"prefix":"10.1111","volume":"176","author":[{"given":"Joshua B","family":"Kohl","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine Cologne University of Cologne Cologne 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