{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:25:36Z","timestamp":1789579536902,"version":"build-2803163510"},"reference-count":147,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["201511\/2014\u20102"],"award-info":[{"award-number":["201511\/2014\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>In this review, we describe the experimental paradigms used in preclinical studies to unravel the histaminergic brain circuits that modulate the formation and retrieval of memories associated with aversive events. Emotionally arousing events, especially bad ones, are remembered more accurately, clearly and for longer periods of time than neutral ones. Maladaptive elaborations of these memories may eventually constitute the basis of psychiatric disorders such as generalized anxiety, obsessive\u2013compulsive disorders and post\u2010traumatic stress disorder. A better understanding of the role of the histaminergic system in learning and memory has not only a theoretical significance but also a translational value. Ligands of histamine receptors are among the most used drugs worldwide; hence, understanding the impact of these compounds on learning and memory may help improve their pharmacological profile and unravel unexplored therapeutic applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.3\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.3\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14476","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T22:43:17Z","timestamp":1534372997000},"page":"557-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Neuronal histamine and the memory of emotionally salient events"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-6848","authenticated-orcid":false,"given":"Gustavo","family":"Provensi","sequence":"first","affiliation":[{"name":"Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-9069","authenticated-orcid":false,"given":"Maria Beatrice","family":"Passani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Costa","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Memory Center, Brain Institute of Rio Grande do Sul Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre RS Brazil"},{"name":"National Institute of Translational Neuroscience (INNT) National Research Council of Brazil  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-3587","authenticated-orcid":false,"given":"Patrizio","family":"Blandina","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino Universit\u00e0 degli Studi di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.42.082701.145401"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13878"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00213-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01689"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/302832a0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02005.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.09.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/253362a0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80024-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000181"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506109112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001514"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.68004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb16086.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00033"},{"key":"e_1_2_9_18_1","first-page":"149","article-title":"Central histaminergic system interactions and cognition","volume":"98","author":"Blandina P","year":"2006","journal-title":"EXS"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001501"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(74)91545-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01885-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805284105"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02092.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2001.01361.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05046.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-003-0325-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148484"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2006.01.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.10.020"},{"key":"e_1_2_9_30_1","first-page":"193","article-title":"Memory facilitation by histamine","volume":"283","author":"Almeida MA","year":"1986","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423465112"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.08.025"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01867"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8697-6"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3144-11.2011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902630102"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604841113"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-90"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050768"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00379-5"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01921"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0580-17.2017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.10.016"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.10.017"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.12.017"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.158444"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06765.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00079.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09016.2003"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90905-1"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01968810"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2007"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01707-1"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00290-0"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.05.081"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730302"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90109-0"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033240"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.07.005"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2015"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200011000-00001"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3825"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01427.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4000"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01835-3"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00264-J"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2271"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.01.002"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1431-0"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.013474"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90077-C"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1424135"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025048802629"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.155"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-04-01523.1996"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20305"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.897"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00088-0"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06249.x"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91240-H"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.58"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-014954"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301209110"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5451.248"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02211-7"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504436102"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.120311"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90108-2"},{"issue":"1","key":"e_1_2_9_90_1","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1007\/PL00022441","article-title":"Subcellular distribution of histamine in mouse brain neurons","volume":"51","author":"Michelsen KA","year":"2002","journal-title":"Inflamm Res"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03033.x"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.121208.131631"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.014"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.01.021"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00262-6"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02733986"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2647"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.18.8477"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2012.00014"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.010249"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3526"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90007-9"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2572"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(99)00053-6"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.08.007"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.171306"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01780.x"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.04.014"},{"key":"e_1_2_9_109_1","volume-title":"Conditioned Reflexes. An Investigation of the Physiological Activity of the Cerebral Cortex","author":"Pavlov IP","year":"1927"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.015"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014119"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8721.2008.00565.x"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00135-5"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022627799"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7427(03)00086-8"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900097"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.07.002"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322016111"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyw110"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091120"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0600-0"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0026187"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09570.1999"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.11.007"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-08177.2000"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_12"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.11.014"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.1.1"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01509-9"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609230103"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00401.2000"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00216-0"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3987.1037"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00212.x"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.70204"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00051"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01454"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07241.x"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.037"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-j0002.2000"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2017.0209"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90034-R"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90308-7"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10043"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2685-05.2006"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.05.001"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00925-7"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301691110"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.14476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.14476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.14476","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.14476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:24:55Z","timestamp":1693808695000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.14476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,18]]},"references-count":147,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/bph.14476"],"URL":"https:\/\/doi.org\/10.1111\/bph.14476","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,18]]},"assertion":[{"value":"2018-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}