{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:36:18Z","timestamp":1787236578549,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81760657 and 81660608"],"award-info":[{"award-number":["No.81760657 and 81660608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660608"],"award-info":[{"award-number":["81660608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760657"],"award-info":[{"award-number":["81760657"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>IL\u20101\u03b2 is a cytokine of critical importance in inflammatory, infectious and autoimmune diseases. Zinc finger protein 91 (ZFP91) has been reported to be involved in multiple biological processes. Here, we identified a previously unknown role for ZFP91 in the production of biologically active IL\u20101\u03b2 and investigated the underlying mechanisms of its effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      , the underlying mechanisms of ZFP91 at inhibiting the expression of IL\u20101\u03b2 were investigated by ELISA, RT\u2010PCR, Western blotting, immunoprecipitation and immunofluorescence assays.\n                      <jats:italic>In vivo<\/jats:italic>\n                      , colitis was induced by giving 4% dextran sulfate sodium (DSS) p.o. in drinking water for 5\u00a0days. Peritonitis was induced by injecting 700\u00a0\u03bcg alum i.p. for 12\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      ZFP91 activated the non\u2010canonical caspase\u20108 inflammasome, which resulted in robust IL\u20101\u03b2 secretion. Using an immunoprecipitation assay and immunofluorescence assay, we found that ZFP91 promoted the assembly of the non\u2010canonical caspase\u20108 inflammasome complex. Moreover, ZFP91 enhanced the activation of ERK, p38 MAPK and JNK in macrophages. In addition, our data demonstrate that the synthesis of pro\u2010IL\u20101\u03b2 is dependent on activation of these MAPK signalling pathways.\n                      <jats:italic>In vivo<\/jats:italic>\n                      experiments, the symptoms and colonic inflammation associated with DSS\u2010induced colitis were ameliorated in mice deficient in ZFP91. Furthermore, the inflammation in alum\u2010induced peritonitis was also attenuated in mice deficient in ZFP91.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Our research describes a mechanism by which ZFP91 promotes production of IL\u20101\u03b2 under physiological conditions and suggests that ZFP91 may be a promising therapeutic target for intervention in inflammatory, infectious and autoimmune\u2010related diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14493","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T21:03:22Z","timestamp":1536095002000},"page":"4338-4352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Zinc finger protein 91 positively regulates the production of IL\u20101\u03b2 in macrophages by activation of MAPKs and non\u2010canonical caspase\u20108 inflammasome"],"prefix":"10.1111","volume":"175","author":[{"given":"Chunliu","family":"Mi","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy Yanbian University  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of 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