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The potent cytoprotective effects of NO have been demonstrated in a range of animal models. However, in some disease states, inhibition of NO synthesis is beneficial. Several attempts have been made to develop drugs for ulcerative and\/or inflammatory disorders of the gastrointestinal tract, with varying degrees of success. Covalently linking a NO\u2010releasing group to non\u2010steroidal anti\u2010inflammatory drugs or to drugs used in the treatment of inflammatory bowel disease and irritable bowel syndrome has shown some benefit, although no drug of this type has yet been fully developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. 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