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In this study, we determined the importance of fatty acids in the life habitat of <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content>; we tested our lipopeptide library in an attempt to create potent <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content>\u2010specific antimicrobial agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Antimicrobial activity was determined by the minimal inhibitory concentration (MIC). Lipids from <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content> were used to explore the mode of action. RAW264.7 cells respectively stimulated with LPS and <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content> were used to measure the anti\u2010inflammatory activity. Mice ears injected with <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content> were used to assess the antimicrobial and anti\u2010inflammatory effects of the peptides tested in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The most potent candidate, C16\u2010KWKW, was observed to be more active against <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes,<\/jats:italic><\/jats:styled-content> with an MIC of 2\u00a0\u03bcg\u00b7ml<jats:sup>\u22121<\/jats:sup>, than against other non\u2010targeted bacterial strains, such as <jats:styled-content style=\"fixed-case\"><jats:italic>Streptococcus mutans<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content>. The mode of action of C16\u2010KWKW was observed to be through interference with the integrity of bacterial membrane, thereby impairing membrane permeability and causing leakage of the inner contents of bacterial cells. In addition, C16\u2010KWKW inhibited the expression of pro\u2010inflammatory cytokines, such as IL\u20101\u03b2, TNF\u2010\u03b1, and inducible NOS, stimulated by both LPS and <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content>, thus showing potential anti\u2010inflammatory activity, which was further assessed in animal studies in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>C16\u2010KWKW is a lipopeptide displaying both anti\u2010<jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content> and anti\u2010inflammatory effects in vitro and in vivo, and exhibits potential as a treatment for acne vulgaris induced by <jats:styled-content style=\"fixed-case\"><jats:italic>P.\u00a0acnes<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14571","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T12:43:12Z","timestamp":1547556192000},"page":"1603-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Retracted<\/i>: Short lipopeptides specifically inhibit the growth of <scp><i>Propionibacterium acnes<\/i><\/scp> with dual antibacterial and anti\u2010inflammatory action"],"prefix":"10.1111","volume":"176","author":[{"given":"Guang","family":"Yang","sequence":"first","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural 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