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This study aimed to elucidate potential contributors to schizophrenia \u201cdysconnectivity.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Western blot analysis was used to compare protein levels of myelin basic protein, neurofilament heavy, autophagosome marker LC3, and microtubule marker \u03b1\u2010tubulin in post\u2010mortem human CB, CC, and AF in schizophrenia subjects (SZ) and matched normal controls (NC). Additionally, SZ cases were subdivided by treatment status: off\u2010medication (OFF) or on\u2010medication (ON).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In the CC, the combined SZ group exhibited less neurofilament heavy protein than the NCs. In the CB, the combined SZ group had similar levels of \u03b1\u2010tubulin protein versus NC, but OFF subjects had increased \u03b1\u2010tubulin protein versus ON and NCs. There were significant correlations between \u03b1\u2010tubulin and all other proteins but only in the CB. The strong negative relationship between \u03b1\u2010tubulin versus myelin basic protein and \u03b1\u2010tubulin versus LC3 in NCs was absent in SZs; coefficients comparison showed significant differences. Preliminary race analyses revealed that African American SZ had less AF \u03b1\u2010tubulin than Caucasian SZ and African American normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>The results show a relationship between tract\u2010 and protein\u2010specific abnormalities and diagnosis, treatment, and race. These data suggest there is a dysregulation of the relationship between \u03b1\u2010tubulin and the other markers of white matter integrity observed in the CB in schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14612","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T16:40:02Z","timestamp":1549644002000},"page":"1143-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pathology of white matter integrity in three major white matter fasciculi: A post\u2010mortem study of schizophrenia and treatment status"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-7887","authenticated-orcid":false,"given":"Kirsten E.","family":"Schoonover","sequence":"first","affiliation":[{"name":"Department of Psychology and Behavioral Neuroscience University of Alabama at Birmingham  Birmingham AL 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