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After the existence of this subtype had been suggested to be present in the heart, studies focused on its role in cardiac function. While the presence and functional role of \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptors in the heart has not uniformly been detected, there is a broad consensus that they become up\u2010regulated in pathological conditions associated with increased sympathetic activity such as heart failure and diabetes. When detected, the \u03b2<jats:sub>3<\/jats:sub>\u2010adrenceptor has been demonstrated to mediate negative inotropic effects in an inhibitory G protein\u2010dependent manner through the NO\u2013cGMP\u2013PKG signalling pathway. 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