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The CB\n                    <jats:sub>1<\/jats:sub>\n                    receptors are present in both inhibitory and excitatory presynaptic terminals and the CB\n                    <jats:sub>2<\/jats:sub>\n                    receptors are found in neuronal subpopulations in addition to microglial cells and astrocytes and are present in both presynaptic and postsynaptic terminals. Subsequent to the discovery of the endocannabinoid (eCB) system, studies have suggested that alcohol alters the eCB system and that this system plays a major role in the motivation to abuse alcohol. Preclinical studies have provided evidence that chronic alcohol consumption modulates eCBs and expression of CB\n                    <jats:sub>1<\/jats:sub>\n                    receptors in brain addiction circuits. In addition, studies have further established the distinct function of the eCB system in the development of fetal alcohol spectrum disorders. This review provides a recent and comprehensive assessment of the literature related to the function of the eCB system in alcohol abuse disorders.\n                  <\/jats:p>","DOI":"10.1111\/bph.14780","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T16:29:11Z","timestamp":1562084951000},"page":"3085-3109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Distinct functions of endogenous cannabinoid system in alcohol abuse disorders"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-8078","authenticated-orcid":false,"given":"Balapal S.","family":"Basavarajappa","sequence":"first","affiliation":[{"name":"Division of Analytical Psychopharmacology Nathan Kline Institute for Psychiatric Research  Orangeburg NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"},{"name":"Department of Psychiatry, College of Physicians and Surgeons Columbia University  New York NY USA"},{"name":"Department of Psychiatry New York University Langone Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Analytical Psychopharmacology Nathan Kline Institute for Psychiatric Research  Orangeburg NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Division of Analytical Psychopharmacology Nathan Kline Institute for Psychiatric Research  Orangeburg NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumar","family":"Subbanna","sequence":"additional","affiliation":[{"name":"Division of Analytical Psychopharmacology Nathan Kline Institute for Psychiatric Research  Orangeburg NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2009.00562.x"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.06.025"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.002"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13878"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13879"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13884"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050326"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci5040456"},{"key":"e_1_2_15_11_1","first-page":"77","volume-title":"Synaptic plasticity: New research","author":"Basavarajappa B. 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