{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:01:37Z","timestamp":1790928097209,"version":"4.1.0"},"reference-count":154,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["13140871"],"award-info":[{"award-number":["13140871"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Resveratrol (trans\u20103,4\u2032,5\u2010trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti\u2010inflammatory, anti\u2010proliferative, and angio\u2010regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol\u2010mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol\u2010induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti\u2010aging agent against several age\u2010associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linked Articles<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.6\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.6\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14801","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T03:58:13Z","timestamp":1564113493000},"page":"1258-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Pharmacological basis and new insights of resveratrol action in the cardiovascular system"],"prefix":"10.1111","volume":"177","author":[{"given":"Chak Kwong","family":"Cheng","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang\u2010Yun","family":"Luo","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Wai","family":"Lau","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Food and Nutritional Sciences Programme, School of Life Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-6784","authenticated-orcid":false,"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2016.04.047"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13880"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13882"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13883"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.050"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100140"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.06.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-017-0038-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.017"},{"issue":"20","key":"e_1_2_10_13_1","first-page":"7456","article-title":"Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models","volume":"61","author":"Bhat K. 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